Regulation of PC12 Cell Differentiation by cAMP Signaling to ERK Independent of PKA: Do All the Connections Add Up?
| Autor: | Lee E. Eiden, Matthew J. Gerdin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
MAPK/ERK pathway
MAP Kinase Signaling System Cellular differentiation Adenylate kinase Neuropeptide Cell Differentiation General Medicine Biology Adenosine Cyclic AMP-Dependent Protein Kinases PC12 Cells Second Messenger Systems Article Cell biology Rats Second messenger system medicine Cyclic AMP Animals Signal transduction Protein kinase A Extracellular Signal-Regulated MAP Kinases medicine.drug |
| Popis: | Pituitary adenylate cyclase–activating polypeptide (PACAP) is a neuropeptide that elevates adenosine 3′,5′-monophosphate (cyclic AMP, also abbreviated cAMP) to elicit neuritogenesis in PC12 cells. This effect appears to be independent of cAMP-dependent protein kinase (PKA) yet dependent on cAMP, leading to the conclusion that another cAMP-binding protein and subsequent signaling pathway must exist to mediate this PKA-independent signaling mechanism. Such a protein was identified as exchange protein directly activated by cAMP (EPAC). Although EPAC may play an indirect role in PACAP-mediated neuritogenesis, it does not serve as the only PKA-independent link from cAMP that leads to neuritogenesis. Thus, the challenge remains to construct a signaling network that incorporates the known mediators, working independently of PKA, that are ultimately responsible for PACAP-mediated neuritogenesis. |
| Databáze: | OpenAIRE |
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