Resveratrol ameliorates inflammatory and oxidative stress in type 2 diabetic Goto-Kakizaki rats
| Autor: | Monika Okulicz, Iwona Hertig, Tomasz Szkudelski, Katarzyna Szkudelska |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Anti-Inflammatory Agents Adipose tissue Inflammation RM1-950 Resveratrol medicine.disease_cause Antioxidants Diabetes Mellitus Experimental Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Blood serum Internal medicine medicine Animals Interleukin 6 Pharmacology chemistry.chemical_classification biology business.industry Glutathione peroxidase Diabetes ROS General Medicine Rats Disease Models Animal Oxidative Stress 030104 developmental biology Endocrinology chemistry Diabetes Mellitus Type 2 Liver 030220 oncology & carcinogenesis biology.protein Cytokines Therapeutics. Pharmacology Lipid Peroxidation medicine.symptom Inflammation Mediators business Oxidative stress Biomarkers |
| Zdroj: | Biomedicine & Pharmacotherapy, Vol 125, Iss, Pp 110026-(2020) |
| ISSN: | 1950-6007 |
| Popis: | Type 2 diabetes is associated with inflammatory and oxidative stress. Resveratrol, a naturally occurring diphenolic compound, was shown to improve glycemic control and alleviate metabolic disturbances in Goto-Kakizaki (GK) rats, a non-obese model of type 2 diabetes. However, in GK rats effects of resveratrol addressing inflammatory and oxidative stress were not explored. The present study aimed to determine anti-inflammatory and anti-oxidative properties of resveratrol in these rats. GK and Sprague-Dawley (SD) rats were divided into 4 groups: GK control, GK treated with resveratrol, SD control and SD treated with resveratrol. Resveratrol (20 mg/kg b.w.) was given once a day for 10 weeks. It was shown that contents of inflammatory markers, interleukin 6 (IL-6), interleukin 1 β (IL-1β), tumor necrosis factor α (TNF-α) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), were increased in the skeletal muscle of diabetic rats, but these effects were prevented by resveratrol therapy. Similarly, amounts of IL-1β and TNF-α were elevated in livers of GK rats; however, this rise was alleviated in resveratrol-treated animals. Moreover, the contents of inflammation-related factors (IL-6, IL-1β, TNF-α and NF-κB) were augmented in adipose tissue of GK rats; nevertheless, in this tissue resveratrol was ineffective. Resveratrol reduced also lipid peroxidation in the skeletal muscle, reduced activities of glutathione peroxidase in blood serum and catalase in the livers of GK rats. Our new findings show that resveratrol therapy results in relieving inflammatory and oxidative stress in GK rats, which may be largely associated with the alleviation of metabolic disturbances in this model of diabetes. Nevertheless, it was demonstrated that the efficacy of resveratrol action is tissue-specific. |
| Databáze: | OpenAIRE |
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