Adolescent Dietary Habit-induced Obstetric and Gynecologic Disease (ADHOGD) as a New Hypothesis—Possible Involvement of Clock System
| Autor: | Hiroshi Fujiwara, Hiroaki Yoshikawa, Yoshiko Maida, Rieko Nakata, Hitoshi Ando, Michihiro Mieda, Naomi Sekizuka-Kagami, Tomoko Fujiwara, Takiko Daikoku, Masanori Ono |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Hypothalamo-Hypophyseal System breakfast skipping clock gene Physiology lcsh:TX341-641 Disease dysmenorrhea young adulthood Young Adult 03 medical and health sciences 0302 clinical medicine Biological Clocks medicine Humans Nutritional Physiological Phenomena 030212 general & internal medicine Young adult Meals Menstruation Disturbances Breakfast Meal 030219 obstetrics & reproductive medicine Nutrition and Dietetics business.industry Reproduction Ovary Breakfast skipping Feeding Behavior Hypothesis CLOCK Irregular menstruation ADHOGD obstetric and gynecological diseases Adolescent Behavior adolescent dieting Etiology Female medicine.symptom business Genital Diseases Female lcsh:Nutrition. Foods and food supply Food Science Dieting |
| Zdroj: | Nutrients, Vol 12, Iss 1294, p 1294 (2020) Nutrients |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu12051294 |
| Popis: | There are growing concerns that poor dietary behaviors at young ages will increase the future risk of chronic diseases in adulthood. We found that female college students who skipped breakfast had higher incidences of dysmenorrhea and irregular menstruation, suggesting that meal skipping affects ovarian and uterine functions. Since dysmenorrhea is more prevalent in those with a past history of dieting, we proposed a novel concept that inadequate dietary habits in adolescence become a trigger for the subsequent development of organic gynecologic diseases. Since inadequate feeding that was limited during the non-active phase impaired reproductive functions in post-adolescent female rats, we hypothesize that circadian rhythm disorders due to breakfast skipping disrupts the hypothalamic–pituitary–ovarian axis, impairs the reproductive rhythm, and leads to ovarian and uterine dysfunction. To explain how reproductive dysfunction is memorized from adolescence to adulthood, we hypothesize that the peripheral clock system also plays a critical role in the latent progression of reproductive diseases together with the central system, and propose naming this concept “adolescent dietary habit-induced obstetric and gynecologic disease (ADHOGD)”. This theory will contribute to analyzing the etiologies of and developing prophylaxes for female reproductive diseases from novel aspects. In this article, we describe the precise outline of the above hypotheses with the supporting evidence in the literature. |
| Databáze: | OpenAIRE |
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