Contrast-Enhanced Quantitative Intravascular Elastography: The Impact of Microvasculature on Model-Based Elastography
| Autor: | Marvin M. Doyley, Steven J. Huntzicker, Himanshu Shekhar |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Materials science Acoustics and Ultrasonics media_common.quotation_subject Biophysics Contrast Media 030204 cardiovascular system & hematology Sensitivity and Specificity Article 030218 nuclear medicine & medical imaging 03 medical and health sciences Elasticity Imaging Techniques 0302 clinical medicine Elastic Modulus Image Interpretation Computer-Assisted Intravascular ultrasound medicine Humans Contrast (vision) Computer Simulation Radiology Nuclear Medicine and imaging Microvessel Ultrasonography Interventional media_common Stress recovery Radiological and Ultrasound Technology medicine.diagnostic_test Phantoms Imaging Fibrous cap Coronary Stenosis Models Cardiovascular Reproducibility of Results Plaque rupture Image Enhancement medicine.anatomical_structure Microvessels Stress Mechanical Elastography Radiology Shear Strength Biomedical engineering |
| Zdroj: | Ultrasound in Medicine & Biology. 42:1167-1181 |
| ISSN: | 0301-5629 |
| Popis: | Model-based intravascular ultrasound elastography visualizes the stress distribution within vascular tissue – information that clinicians could use to predict the propensity of atherosclerotic plaque rupture. However, there are concerns that clusters of microvessels may reduce the accuracy of the estimated stress distribution. Consequently, we have developed a contrast-enhanced intravascular ultrasound system to investigate how plaque microvasculature impacts the performance of model-based elastography. In simulations diameters of 200,400, and 800 microns were used, where the latter diameter represented a cluster of microvessels. In phantoms, we used a microvessel with diameter of 750 microns. Peak stress errors of 3% and 38% were incurred in the fibrous cap when stress recovery was performed with and without a priori information about microvessels geometry. The results demonstrate that incorporating geometrical information about plaque microvasculature obtained with contrast-enhanced ultrasound imaging improves the accuracy of estimates of the stress distribution within the fibrous cap precisely. |
| Databáze: | OpenAIRE |
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