Nickel-Catalyzed Negishi Cross-Coupling of Bromodifluoroacetamides
| Autor: | Saori Shinohara, Kazuyuki Sato, Masaaki Omote, Atsushi Tarui, Akira Ando |
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| Rok vydání: | 2016 |
| Předmět: |
Coupling
010405 organic chemistry Ligand Negishi coupling Aryl Organic Chemistry chemistry.chemical_element 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Catalysis Nickel chemistry.chemical_compound chemistry Reagent Amide Organic chemistry Physical and Theoretical Chemistry |
| Zdroj: | Organic letters. 18(5) |
| ISSN: | 1523-7052 |
| Popis: | A nickel-catalyzed Negishi coupling of bromodifluoroacetamides with arylzinc reagents has been developed. This reaction allows access to difluoromethylated aromatic compounds containing a variety of aryl groups and amide moieties. Furthermore, highly effective transformation of the functionalized difluoromethyl group (-CF2CONR(1)R(2)) was realized via microwave-assisted reduction under mild conditions. The notable features of this strategy are its generality and its use of a low-cost nickel catalyst and ligand; thus, this reaction provides a facile method for applications in drug discovery and development. |
| Databáze: | OpenAIRE |
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