Familial Risk and Heritability of Colorectal Cancer in the Nordic Twin Study of Cancer
| Autor: | Rebecca E. Graff, Eero Pukkala, Edward Giovannucci, Lorelei A. Mucci, Axel Skytthe, Qihua Tan, Sören Möller, Jaakko Kaprio, Kaare Christensen, Kamila Czene, Michael N. Passarelli, Jennifer R. Harris, Hans-Olov Adami, Jacob v. B. Hjelmborg, John S. Witte |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Colorectal cancer Twins Individuality Concordance Relative Risk Genetic Susceptibility 0302 clinical medicine 80 and over Twins Dizygotic Young adult Child Cancer Aged 80 and over Gastroenterology Zygosity Middle Aged Colo-Rectal Cancer 3. Good health Europe 030220 oncology & carcinogenesis Rectal Neoplasms/epidemiology Child Preschool Colonic Neoplasms Cohort Female Risk assessment Adult medicine.medical_specialty Adolescent Clinical Sciences biometric modeling Risk Assessment Article Monozygotic Europe/epidemiology 03 medical and health sciences Young Adult Clinical Research Internal medicine Dizygotic Genetics medicine Genetic predisposition Humans Genetic Predisposition to Disease Genetic Testing Preschool Aged Family Health Colonic Neoplasms/epidemiology Gastroenterology & Hepatology Hepatology Rectal Neoplasms business.industry Prevention Human Genome Infant Twins Monozygotic Heritability medicine.disease Twin study 030104 developmental biology Digestive Diseases business Demography |
| Zdroj: | Graff, R E, Möller, S, Passarelli, M N, Witte, J S, Skytthe, A, Christensen, K, Tan, Q, Adami, H-O, Czene, K, Harris, J R, Pukkala, E, Kaprio, J, Giovannucci, E, Mucci, L A & Hjelmborg, J B 2017, ' Familial Risk and Heritability of Colorectal Cancer in the Nordic Twin Study of Cancer ', Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, vol. 15, no. 8, pp. 1256-1264 . https://doi.org/10.1016/j.cgh.2016.12.041 Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, vol 15, iss 8 |
| Popis: | Background & Aims We analyzed data from twins to determine how much the familial risk of colorectal cancer can be attributed to genetic factors vs environment. We also examined whether heritability is distinct for colon vs rectal cancer, given evidence of distinct etiologies. Methods Our data set included 39,990 monozygotic and 61,443 same-sex dizygotic twins from the Nordic Twin Study of Cancer. We compared each cancer's risk in twins of affected co-twins relative to the cohort risk (familial risk ratio [FRR]). We then estimated the proportion of variation in risk that could be attributed to genetic factors (heritability). Results From earliest registration in 1943 through 2010, there were 1861 individuals diagnosed with colon cancer and 1268 diagnosed with rectal cancer. Monozygotic twins of affected co-twins had an FRR for colorectal cancer of 3.1 (95% confidence interval [CI], 2.4–3.8) relative to the cohort risk. Dizygotic twins of affected co-twins had an FRR for colorectal cancer of 2.2 (95% CI, 1.7–2.7). We estimated that 40% (95% CI, 33%–48%) of the variation in colorectal cancer risk could be attributed to genetic factors; unique environment only accounted for the remaining liability. For colon cancer, the FRR was 3.3 (95% CI, 2.1–4.5) for monozygotic twins and 2.6 (95% CI, 1.7–3.5) for dizygotic twins. For rectal cancer, comparable estimates were 3.3 (95% CI, 1.5–5.1) for monozygotic twins and 2.6 (95% CI, 1.2–4.0) for dizygotic twins. Heritability estimates for colon and rectal cancer were 16% (95% CI, 0–46%) and 15% (95% CI, 0–50%), common environment estimates were 15% (95% CI, 0–38%) and 11% (95% CI, 0–38%), and unique environment estimates were 68% (95% CI, 57%–79%) and 75% (95% CI, 61%–88%), respectively. Conclusions Interindividual genetic differences could account for 40% of the variation in susceptibility to colorectal cancer; risk for colon and rectal cancers might have less of a genetic component than risk for colorectal cancer. Siblings, and particularly monozygotic co-twins, of individuals with colon or rectal cancer should consider personalized screening. |
| Databáze: | OpenAIRE |
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