Dynamic modeling for modulation of ATP concentration at the endothelial surface by viscous shear flow

Autor:	Cheng Xiang, Hui Zhang, Shuzhi Sam Ge, Zonglai Jiang, Zhe Xu, Kairong Qin
Rok vydání:	2006
Předmět:	Stress (mechanics) chemistry.chemical_classification chemistry.chemical_compound Enzyme chemistry ATP hydrolysis Diffusion Shear stress Biophysics Mechanotransduction Shear flow Adenosine triphosphate
Zdroj:	2006 IEEE Conference on Computer Aided Control System Design, 2006 IEEE International Conference on Control Applications, 2006 IEEE International Symposium on Intelligent Control.
DOI:	10.1109/cacsd-cca-isic.2006.4776825
Popis:	In this paper, dynamic modeling is investigated for shear stress induced adenosine triphosphate (ATP) release from endothelial cells (ECs). The modulation of ATP concentration at the endothelial surface by viscous shear flow is extensively investigated through numerical analysis based on the release model. The simulation results demonstrate that shear stress induced ATP release, convection and diffusion of ATP, and ATP hydrolysis by ecto-ATPase synergistically determine the ATP concentration against time at endothelium-fluid interface.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f04cbddafc3bd4969fce7fbf6c700e https://doi.org/10.1109/cacsd-cca-isic.2006.4776825 Zobrazit plný text záznamu