Propylene carbonate quantification by its derivative 3,5-diacetyl-1,4-dihydro-2,6-lutidine
| Autor: | Edina Vranić, Alf Lamprecht, Diana Imhof, Daris Grizić, Pascal Heimer |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pyridines
Calibration curve Analytical chemistry Diacetyl 02 engineering and technology Derivative 01 natural sciences Mass Spectrometry Analytical Chemistry Propane chemistry.chemical_compound Spectrophotometry Calibration medicine Chromatography Molecular Structure medicine.diagnostic_test 010401 analytical chemistry Temperature Reproducibility of Results Linearity Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology 0104 chemical sciences Solvent Spectrometry Fluorescence Models Chemical chemistry Propylene carbonate Curve fitting 0210 nano-technology Chromatography Liquid |
| Zdroj: | Talanta. 151:75-82 |
| ISSN: | 0039-9140 |
| Popis: | Propylene carbonate (PC) is a non-toxic solvent currently used in various pharmaceutical formulations. Consequently, a simple, cost-effective and most accurate analytical method for the quantification of this optical inert solvent is of major interest. Based on a consecutive three-step reaction 3,5-diacetyl-1,4-dihydro-2,6-lutidine was obtained from PC and used for quantification by either UV and fluorescent detection. Data were compared with results from LC-ESI-MS as a reference method. After using Mandel's test for linearity assessment of the calibration curves, linear fitting was used for LC-ESI-MS and spectrofluorimetry, while a polynomial 3rd order curve fitting was used for spectrophotometry. High intra- and inter-day precision as well as high accuracy were confirmed for all three analytical methods (spectrophotometry, spectrofluorimetry and LC-ESI-MS). The comparison of all three methods was assessed using correlation coefficients and Bland-Altman plots, both showing satisfying results with a high degree of agreement. The new method confirmed its applicability for PC quantification in two formulations, namely a PC-enriched cream and polyester microimplants. This new quantification method for PC is a reliable alternative to highly sophisticated chromatographic methods. |
| Databáze: | OpenAIRE |
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