Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
| Autor: | Liu, M, Jiang, Y, Wedow, R, Li, Y, Brazel, DM, Chen, F, Datta, G, Davila-Velderrain, J, McGuire, D, Tian, C, Zhan, X, Team, 23Andme Research, Psychiatry, Hunt All-In, Choquet, H, Docherty, AR, Faul, JD, Foerster, JR, Fritsche, LG, Gabrielsen, ME, Gordon, SD, Haessler, J, Hottenga, J-J, Huang, H, Jang, S-K, Jansen, PR, Ling, Y, Mägi, R, Matoba, N, McMahon, G, Mulas, A, Orrù, V, Palviainen, T, Pandit, A, Reginsson, GW, Skogholt, AH, Smith, JA, Taylor, AE, Turman, C, Willemsen, G, Young, H, Young, KA, Zajac, GJM, Zhao, W, Zhou, W, Bjornsdottir, G, Boardman, JD, Boehnke, M, Boomsma, DI, Chen, C, Cucca, F, Davies, GE, Eaton, CB, Ehringer, MA, Esko, T, Fiorillo, E, Gillespie, NA, Gudbjartsson, DF, Haller, T, Harris, KM, Heath, AC, Hewitt, JK, Hickie, IB, Hokanson, JE, Hopfer, CJ, Hunter, DJ, Iacono, WG, Johnson, EO, Kamatani, Y, Kardia, SLR, Keller, MC, Kellis, M, Kooperberg, C, Kraft, P, Krauter, KS, Laakso, M, Lind, PA, Loukola, A, Lutz, SM, Madden, PAF, Martin, NG, McGue, M, McQueen, MB, Medland, SE, Metspalu, A, Mohlke, KL, Nielsen, JB, Okada, Y, Peters, U, Polderman, TJC, Posthuma, D, Reiner, AP, Rice, JP, Rimm, E, Rose, RJ, Runarsdottir, V, Stallings, MC, Stančáková, A, Stefansson, H, Thai, KK, Tindle, HA, Tyrfingsson, T, Wall, TL, Weir, DR, Weisner, C, Whitfield, JB, Winsvold, BS, Yin, J, Zuccolo, L, Bierut, LJ, Hveem, K, Lee, JJ, Munafò, MR, Saccone, NL, Willer, CJ, Cornelis, MC, David, SP, Hinds, DA, Jorgenson, E, Kaprio, J, Stitzel, JA, Stefansson, K, Thorgeirsson, TE, Abecasis, G, Liu, DJ, Vrieze, S |
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| Přispěvatelé: | Biological Psychology, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, Complex Trait Genetics, Amsterdam Neuroscience - Complex Trait Genetics, APH - Mental Health, APH - Methodology, Human genetics, Amsterdam Reproduction & Development (AR&D), APH - Aging & Later Life, Human Genetics |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Netherlands Twin Register (NTR) Smoking/genetics ved/biology.organism_classification_rank.species Alcohol Genome-wide association study Brain and Behaviour chemistry.chemical_compound 0302 clinical medicine Tobacco Use Disorder/genetics Tobacco/adverse effects Genetics 0303 health sciences Smoking Tobacco and Alcohol public health Tobacco Use Disorder Middle Aged 3. Good health Phenotype psychiatric disorders Genetic Variation/genetics Meta-analysis Genome-Wide Association Study/methods Female Physical and Mental Health Risk Alcohol Drinking psychology Biology Article 03 medical and health sciences SDG 3 - Good Health and Well-being Tobacco Humans Model organism Gene 030304 developmental biology Genetic association ved/biology Genetic Variation Alcohol Drinking/genetics Heritability chemistry genome-wide association studies 030217 neurology & neurosurgery Genome-Wide Association Study |
| Zdroj: | Liu, M, Jiang, Y, Wedow, R, Li, Y, Brazel, D M, Chen, F, Datta, G, Davila-Velderrain, J, McGuire, D, Tian, C, Zhan, X, Agee, M, Alipanahi, B, Auton, A, Bell, R K, Bryc, K, Elson, S L, Fontanillas, P, Furlotte, N A, Hinds, D A, Hromatka, B S, Huber, K E, Kleinman, A, Litterman, N K, McIntyre, M H, Mountain, J L, Northover, C A M, Sathirapongsasuti, J F, Sazonova, O V, Shelton, J F, Shringarpure, S, Tian, C, Tung, J Y, Vacic, V, Wilson, C H, Pitts, S J, Mitchell, A, Skogholt, A H, Winsvold, B S, Sivertsen, B R, Stordal, E, Morken, G, Kallestad, H V, Heuch, I, Zwart, J-A, Fjukstad, K K, Pedersen, L M, Gabrielsen, M E, Jansen, P R, Posthuma, D, 23andMe Research team, Jorgenson, E, Stitzel, J A, Liu, D J & Vrieze, S 2019, ' Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use ', Nature Genetics, vol. 51, no. 2, pp. 237-244 . https://doi.org/10.1038/s41588-018-0307-5 Nature Genetics the 23 and Me Research Team 2019, ' Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use ', Nature Genetics, vol. 51, no. 2, pp. 237-244 . https://doi.org/10.1038/s41588-018-0307-5 Nature Genetics, 51(2), 237-244. Nature Publishing Group Liu, M, Hottenga, J J, Jansen, P R, Willemsen, G, Boomsma, D I, Davies, G E, Polderman, T J C, Posthuma, D, Vrieze, S, 23Andme Research Team & HUNT All-In Psychiatry 2019, ' Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use ', Nature Genetics, vol. 51, no. 2, pp. 237-244 . https://doi.org/10.1038/s41588-018-0307-5 PMC Nature genetics Nature genetics, 51(2), 237-244. Nature Publishing Group |
| ISSN: | 1061-4036 |
| DOI: | 10.1038/s41588-018-0307-5 |
| Popis: | Tobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders1. They are heritable2,3 and etiologically related4,5 behaviors that have been resistant to gene discovery efforts6,7,8,9,10,11. In sample sizes up to 1.2 million individuals, we discovered 566 genetic variants in 406 loci associated with multiple stages of tobacco use (initiation, cessation, and heaviness) as well as alcohol use, with 150 loci evidencing pleiotropic association. Smoking phenotypes were positively genetically correlated with many health conditions, whereas alcohol use was negatively correlated with these conditions, such that increased genetic risk for alcohol use is associated with lower disease risk. We report evidence for the involvement of many systems in tobacco and alcohol use, including genes involved in nicotinic, dopaminergic, and glutamatergic neurotransmission. The results provide a solid starting point to evaluate the effects of these loci in model organisms and more precise substance use measures. © 2019. This is the authors’ accepted and refereed manuscript to the article. |
| Databáze: | OpenAIRE |
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