Microbial Cold Shock Proteins: Overview of their Function and Mechanism of Action
| Autor: | Guang Chen, Chunjie Tian, Changjie Bao, Sitong Zhang, Yonghong Zhang, Lijun Shen, Xueli Zang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Messenger RNA
Five prime untranslated region Chemistry RNA Translation (biology) General Medicine Cold-shock domain Biochemistry Ribosome Protein Structure Secondary Bacterial Proteins Structural Biology Transcription (biology) Biophysics Cold Shock Proteins and Peptides RNA Messenger Protein secondary structure |
| Zdroj: | Protein and peptide letters. 29(2) |
| ISSN: | 1875-5305 |
| Popis: | The organism responds to a decrease in temperature by producing a series of cold shock proteins (CSPs). These proteins play a critical role in growing and functioning characteristics at low temperatures. CSPs have been discovered in a wide range of organisms and have shown enormous diversity; their mechanisms of action are also complicated. Transcription and translation in microorganisms typically occur via a single linear chain, but upon exposure to low temperatures, RNA forms a complex secondary structure that prevents ribosomes from binding to it, thus slowing down translation. CSPs bind to mRNA as RNA molecular chaperones to keep the mRNA secondary structure in a single-stranded linear conformation, allowing successful translation at low temperatures. |
| Databáze: | OpenAIRE |
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