Mesenchymal stem cell surgery, rescue and regeneration in retinitis pigmentosa: clinical and rehabilitative prognostic aspects
| Autor: | Celeste Limoli, Enzo Maria Vingolo, Paolo G. Limoli, Marco U Morales |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
030506 rehabilitation growth factor (GF) genetic structures Visual Acuity chemistry.chemical_compound 0302 clinical medicine embryonic stem cells (ESC) medicine.diagnostic_test Middle Aged Prognosis foveal thickness medicine.anatomical_structure Treatment Outcome Neurology Female autograft cell surgery induced pluripotent stem cells (iPSCs) Limoli retinal restoration technique (LRRT) mesenchymal cell (MSC) retinitis pigmentosa (RP) 0305 other medical science Erg Retinitis Pigmentosa Tomography Optical Coherence Research Article Adult medicine.medical_specialty Retina 03 medical and health sciences Developmental Neuroscience Statistical significance Retinitis pigmentosa medicine Electroretinography Humans Regeneration business.industry Retinal Mesenchymal Stem Cells medicine.disease eye diseases Surgery Clinical research chemistry Neurology (clinical) Choroid sense organs business Microperimetry 030217 neurology & neurosurgery |
| Zdroj: | Restorative Neurology and Neuroscience |
| Popis: | Purpose To assess whether treatment with the Limoli Retinal Restoration Technique (LRRT) can be performed in patients with retinitis pigmentosa (RP), grafting the autologous cells in a deep scleral pocket above the choroid of each eye to exert their beneficial effect on the residual retinal cells. Methods The patients were subjected to a complete ophthalmological examination, including best corrected visual acuity (BCVA), close-up visus measurements, spectral domain-optical coherence tomography (SD-OCT), microperimetry (MY), and electroretinography (ERG). Furthermore, the complete ophthalmological examination was carried out at baseline (T0) and at 6 months (T180) after surgery. The Shapiro-Wilk test was used to assess the normality of distribution of the investigated parameters. A mixed linear regression model was used to analyse the difference in all the studied parameters at T0 and T180, and to compare the mean change between the two groups. All statistical analyses were performed with STATA 14.0 (Collage Station, Texas, USA). Results LRRT treatment was performed in 34 eyes of 25 RP patients recruited for the study. The eyes were classified in two groups on the basis of foveal thickness (FT) assessed by SD-OCT: 14 eyes in Group A (FT≤190μm) and the remaining 20 ones in Group B (FT > 190μm). Although it had not reached the statistical significance, Group B showed a better improvement in BCVA, residual close-up visus and sensitivity than Group A. Conclusions Previous studies have described the role of LRRT in slowing down retinal degenerative diseases. Consequently, this surgical procedure could improve the clinical and rehabilitative prognostic parameters in RP patients. On the other hand, further clinical research and studies with longer follow-up will be needed to evaluate its efficacy. |
| Databáze: | OpenAIRE |
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