Adipose tissue metabolic and inflammatory responses to a mixed meal in lean, overweight and obese men
| Autor: | Rebecca L. Travers, Dylan Thompson, James A. Betts, Alexandre C. Motta |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Blood Glucose
Male 0301 basic medicine medicine.medical_treatment Adipose tissue Medicine (miscellaneous) White adipose tissue Biochemistry Body Mass Index 0302 clinical medicine Surveys and Questionnaires Insulin Medicine Meals Adiposity Meal Nutrition and Dietetics Postprandial Original Contribution Middle Aged Postprandial Period Cytokines Waist Circumference Human Adult medicine.medical_specialty Adipokine 030209 endocrinology & metabolism 03 medical and health sciences Thinness Internal medicine Humans Obesity Triglycerides Inflammation business.industry Cholesterol HDL Nutritional Requirements Cholesterol LDL Overweight Lipid Metabolism medicine.disease Metabolism 030104 developmental biology Endocrinology Sample Size business Body mass index Food Science |
| Zdroj: | European Journal of Nutrition |
| ISSN: | 1436-6207 |
| DOI: | 10.1007/s00394-015-1087-7 |
| Popis: | Purpose Most of what we know about adipose tissue is restricted to observations derived after an overnight fast. However, humans spend the majority of waking hours in a postprandial (fed) state, and it is unclear whether increasing adiposity impacts adipose tissue responses to feeding. The aim of this research was to investigate postprandial responses in adipose tissue across varying degrees of adiposity. Methods Thirty males aged 35–55 years with waist circumference 81–118 cm were divided equally into groups categorized as either lean, overweight or obese. Participants consumed a meal and insulinaemic, glycaemic and lipidaemic responses were monitored over 6 h. Subcutaneous adipose tissue samples were obtained at baseline and after 6 h to examine changes in gene expression and adipose tissue secretion of various adipokines. Results Following consumption of the meal, insulin and glucose responses were higher with increased adiposity (total AUC effects of group; p = 0.058 and p = 0.027, respectively). At 6 h, significant time effects reflected increases in IL-6 (F = 14.7, p = 0.001) and MCP-1 (F = 10.7, p = 0.003) and reduction in IRS2 adipose tissue gene expression (F = 24.6, p |
| Databáze: | OpenAIRE |
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