The Influence of Calcification Factors and Endothelial-Dysfunction Factors on the Development of Unstable Atherosclerotic Plaques
| Autor: | Yuliya I. Ragino, E.M. Stakhneva, Aleksei V Kurguzov, N. A. Maslatsov, Ivan S. Murashov, Alexander M. Chernyavskii, Y. Polonskaya, Elena V. Kashtanova, E.V. Sadovski |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty osteopontin unstable atherosclerotic plaque medicine.medical_treatment Clinical Biochemistry osteocalcin sVCAM 030204 cardiovascular system & hematology Article 03 medical and health sciences 0302 clinical medicine Medicine 030212 general & internal medicine Osteopontin Endothelial dysfunction Coronary atherosclerosis Endarterectomy lcsh:R5-920 biology osteonectin business.industry E-selectin medicine.disease Coronary arteries medicine.anatomical_structure Osteocalcin biology.protein calcification of atherosclerotic plaques business lcsh:Medicine (General) Calcification Artery |
| Zdroj: | Diagnostics, Vol 10, Iss 1074, p 1074 (2020) Diagnostics Volume 10 Issue 12 |
| ISSN: | 2075-4418 |
| Popis: | Background: This study aimed to evaluate changes in markers of calcification and of endothelial dysfunction during the development of calcification and instability of atherosclerotic plaques and to identify associations of calcification factors with the formation of unstable plaques. Methods: We analyzed 44 male patients with coronary atherosclerosis who underwent endarterectomy in coronary arteries during coronary bypass surgery. The endarterectomy material (intima/media) was examined using histological and biochemical methods, and the stability and calcification degree of atherosclerotic plaques were assessed. In homogenates of the tissue samples and in blood, concentrations of osteoprotegerin, osteocalcin, osteopontin, osteonectin, monocyte-chemoattractant protein type 1 (MCP-1), soluble vascular cell adhesion molecule 1 (sVCAM-1), and E-selectin were determined by enzyme immunoassays. Results: Unstable atherosclerotic plaques proved to be calcified more frequently (80.4% of plaques) than stable ones (45.0%). Osteonectin, E-selectin, and sVCAM-1 levels were lower in unstable plaques and plaques with large calcification deposits. Osteocalcin content increased with the increasing size of the calcification deposits in plaque. Blood osteocalcin concentration directly correlated with osteocalcin concentration in atherosclerotic plaques and was higher in the blood of patients with calcified plaques in coronary arteries. Conclusions: The results provide the basis for further research on the suitability of osteocalcin as a potential biomarker of an unstable calcified atherosclerotic plaque in a coronary artery. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|