Piezo1 Channels Are Inherently Mechanosensitive
| Autor: | Ardem Patapoutian, Ruhma Syeda, Jennifer M. Kefauver, Charles D. Cox, Jose S. Santos, Maria N. Florendo, Boris Martinac |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Osmosis Cell type Lipid Bilayers Biology Mechanotransduction Cellular Ion Channels Article General Biochemistry Genetics and Molecular Biology membrane tension Mice 03 medical and health sciences 0302 clinical medicine Mechanosensitive ion channel Animals Mechanotransduction Lipid bilayer lcsh:QH301-705.5 Ion channel mechanotransduction PIEZO1 Lipid Droplets Piezo1 mechanosensitive ion channel membrane asymmetry Cell biology lipid bilayer Stretch-activated ion channel 030104 developmental biology lcsh:Biology (General) Solvents Mechanosensitive channels Ion Channel Gating 030217 neurology & neurosurgery |
| Zdroj: | Cell Reports, Vol 17, Iss 7, Pp 1739-1746 (2016) |
| ISSN: | 2211-1247 |
| Popis: | SummaryThe conversion of mechanical force to chemical signals is critical for many biological processes, including the senses of touch, pain, and hearing. Mechanosensitive ion channels play a key role in sensing the mechanical stimuli experienced by various cell types and are present in organisms from bacteria to mammals. Bacterial mechanosensitive channels are characterized thoroughly, but less is known about their counterparts in vertebrates. Piezos have been recently established as ion channels required for mechanotransduction in disparate cell types in vitro and in vivo. Overexpression of Piezos in heterologous cells gives rise to large mechanically activated currents; however, it is unclear whether Piezos are inherently mechanosensitive or rely on alternate cellular components to sense mechanical stimuli. Here, we show that mechanical perturbations of the lipid bilayer alone are sufficient to activate Piezo channels, illustrating their innate ability as molecular force transducers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|