MMP-13 Polymorphism as a Risk Factor in Implant Loss
| Autor: | Maria Cristina Dos Santos, Francielle Boçon de Araujo Munhoz, Filipe Polese Branco, Ricardo Lehtonen Rodrigues Souza |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Saliva Adolescent Genotype Gastroenterology Young Adult Risk Factors Internal medicine Statistical significance Matrix Metalloproteinase 13 medicine Humans Dental Restoration Failure Young adult Alleles Aged Dental Implants Chi-Square Distribution Polymorphism Genetic business.industry Case-control study General Medicine Middle Aged Case-Control Studies Female Implant Gene polymorphism Oral Surgery business Chi-squared distribution Polymorphism Restriction Fragment Length |
| Zdroj: | The International journal of oralmaxillofacial implants. 34(3) |
| ISSN: | 1942-4434 |
| Popis: | Purpose To investigate whether MMP-13 g.-77 A > G (rs2252070) gene polymorphism is associated with early implants loss. Materials and methods Two hundred nonsmoking volunteers in good oral health, > 18 years of age, and found to be periodontally healthy by clinical examination were matched by age, sex, and implant position and separated into two groups: control group (100 patients with one or more healthy implants for a minimum of 1 year) and test group (100 patients who had suffered early implant loss, considered when implants presented mobility and/or pain before or during abutment connection, requiring their removal). Genomic DNA from saliva was genotyped by PCR-RFLP. Statistical analysis of the results was done using Mann-Whitney U and chi-square tests, with a significance level of 5%. Results A significant difference in the presence of the different alleles and genotype was found between groups for the MMP-13 g.-77 A > G (rs2252070) gene polymorphism (P = .0161, OR 95% = 0.57 [0.37 to 0.89]; P = .007, OR 95% = 0.44 [0.25 to 0.78]). The A allele increased susceptibility to early implant loss and appeared to be a genetic risk factor. Conclusion The findings suggest that MMP-13 g.-77 A > G (rs2252070) polymorphism may contribute to early implants loss. |
| Databáze: | OpenAIRE |
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