In vitro activities of PD 117,596 and reference antibiotics against 448 clinical bacterial strains
| Autor: | J V Conroy, M C Hammer, R P Smith, A L Baltch |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1988 |
| Předmět: |
Klebsiella
Gram-positive bacteria Colony Count Microbial Quinolones Gram-Positive Bacteria Microbiology Agar dilution Nalidixic Acid Anti-Infective Agents medicine Pharmacology (medical) Antibacterial agent Pharmacology biology Gram-Negative Aerobic Bacteria Enterobacter Acinetobacter biochemical phenomena metabolism and nutrition biology.organism_classification bacterial infections and mycoses Proteus mirabilis Anti-Bacterial Agents Ciprofloxacin Infectious Diseases bacteria medicine.drug Research Article Fluoroquinolones |
| Popis: | The in vitro activity of PD 117,596, a new fluoroquinolone antibiotic, was tested against 448 bacterial isolates (15 genera) by agar dilution (inoculum, 10(4) CFU per spot). The activity of PD 117,596 was compared with that of 15 antibiotics against 327 gram-negative strains and with that of 8 other antibiotics against 121 gram-positive strains. PD 117,596 demonstrated the best activity against Klebsiella spp., Enterobacter spp., Acinetobacter spp., Serratia marcescens, and Branhamella catarrhalis (MICs for 90% of the isolates [MIC90S], 0.008 to 0.25 microgram/ml). PD 117,596 (MIC90, 0.25 microgram/ml) was at least twofold more active than ciprofloxacin against Pseudomonas aeruginosa and Pseudomonas spp. PD 117,596 and ciprofloxacin were similar in activity against Escherichia coli, Proteus mirabilis, Haemophilus influenzae, H. parainfluenzae, Neisseria gonorrhoeae, Legionella pneumophila, and Campylobacter jejuni (MIC90, 0.002 to 0.125 microgram/ml). PD 117,596 was more active than ciprofloxacin against streptococcal groups A, B, C, and G, S. pneumoniae, and enterococci (MIC90S, 0.06 to 0.125 microgram/ml). Against Staphylococcus aureus, including methicillin-resistant isolates, PD 117,596 (MIC90S, 0.03 to 0.06 microgram/ml) was 4- to 16-fold more active than ciprofloxacin and was most active against Corynebacterium spp. PD 117,596 appears to be the most active fluoroquinolone to date, with excellent activity against gram-positive bacteria and enhanced activity against gram-negative aerobic-facultative bacteria. |
| Databáze: | OpenAIRE |
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