Preparation of an Antibacterial Poly(ionic liquid) Graft Copolymer of Hydroxyethyl Cellulose
| Autor: | Neil R. Cameron, Osama M. Musa, Gary J. Sharples, R. Paul Yeo, Fanny Joubert, David R. W. Hodgson |
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| Rok vydání: | 2015 |
| Předmět: |
Bridged-Ring Compounds
TP Staphylococcus aureus RM Polymers and Plastics Polymers Ionic Liquids Bioengineering Microbial Sensitivity Tests medicine.disease_cause Polymerization Biomaterials Structure-Activity Relationship chemistry.chemical_compound Thiocarbamates Polymer chemistry Escherichia coli Materials Chemistry medicine Copolymer Reversible addition−fragmentation chain-transfer polymerization Cellulose Carbon Isotopes Microbial Viability Nitrogen Isotopes Thiones Norbornanes Anti-Bacterial Agents QR Monomer chemistry Ionic liquid Ampicillin Xanthate Hydroxyethyl cellulose |
| Zdroj: | Biomacromolecules, 2015, Vol.16(12), pp.397-3979 [Peer Reviewed Journal] ResearcherID |
| ISSN: | 1526-4602 1525-7797 |
| DOI: | 10.1021/acs.biomac.5b01300 |
| Popis: | Poly(ionic liquid)s (P(IL)s) of different degrees of polymerization (10, 50, and 100) were prepared via RAFT polymerization using an alkyne-terminated xanthate as transfer agent, with a monomer conversion of up to ∼80% and a ĐM of 1.5 for P(IL)100. Subsequently, P(IL) chains were coupled to 15N-labeled azido-functionalized hydroxyethyl cellulose (HEC), forming graft copolymers of HEC with different chain length and graft densities, which were characterized using (13C and 15N) CP-MAS NMR and FT-IR spectroscopies. The antibacterial activities of HEC-g-P(IL)s were tested against Escherichia coli and Staphylococcus aureus and were comparable to ampicillin, a well-known antibiotic, demonstrating efficient activity of the graft copolymers against bacteria. Moreover, HEC-g-P(IL)s were slightly more effective against E. coli than S. aureus. A decrease in graft density of P(IL)10 on the HEC backbone decreased the activity of the graft copolymers against both bacteria. These findings suggest that HEC-g-P(IL) could find applications as an antiseptic compound, for example, in paint formulation.\ud \ud |
| Databáze: | OpenAIRE |
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