Characterization and clinicopathological significance of circulating tumour cells in patients with oral squamous cell carcinoma
| Autor: | Justin Curtin, Siu-Wai Choi, Alfred King-Yin Lam, Peter Thomson |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Oncology
medicine.medical_specialty Malignancy 03 medical and health sciences 0302 clinical medicine Circulating tumor cell Internal medicine Biomarkers Tumor medicine Humans Liquid biopsy Lymph node Squamous Cell Carcinoma of Head and Neck business.industry Melanoma Head and neck cancer Cancer 030206 dentistry Neoplastic Cells Circulating Prognosis medicine.disease medicine.anatomical_structure Otorhinolaryngology Head and Neck Neoplasms 030220 oncology & carcinogenesis Carcinoma Squamous Cell Biomarker (medicine) Mouth Neoplasms Surgery Neoplasm Recurrence Local Oral Surgery business |
| Zdroj: | International Journal of Oral and Maxillofacial Surgery. 51:289-299 |
| ISSN: | 0901-5027 |
| Popis: | Circulating tumour cells (CTCs) are cancer cells released by cancer into the peripheral circulation. Haematogenous tumour spread is a hallmark of metastatic malignancy and a key factor in cancer recurrence and prognosis. CTCs have diagnostic and prognostic significance for a number of adenocarcinomas and melanoma. A review of the published peer-reviewed literature was performed to determine the clinical relevance of CTCs as a biomarker in the management of oral squamous cell carcinoma (OSCC). Fourteen studies met the eligibility criteria. With regard to patients with OSCC, this review found the following: (1) CTCs have been detected using multiple techniques; (2) the presence of CTCs does not appear to be related to tumour differentiation or size; (3) CTCs may be detected without lymph node involvement; (4) the detection of CTCs may be prognostic for both disease-free survival and overall survival; (5) quantification of CTCs may reflect the efficacy of therapy; (6) CTCs may be of value for ongoing patient monitoring. Preliminary evidence suggests that CTCs have diagnostic and prognostic potential as a biomarker for oral cancer management and warrant further investigation to determine their appropriate place in the management of OSCC patients. |
| Databáze: | OpenAIRE |
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