Evaluation of the relationship between serum ghrelin levels and cancer cachexia in patients with locally advanced nonsmall-cell lung cancer treated with chemoradiotherapy
| Autor: | Fulya Yaman Agaoglu, Zeynep Güral, Nevin Fazlıoğlu, Berrin Inanc, Caglar Cuhadaroglu, Volkan Sozer, Cigdem Usul Afsar, Pelin Uysal, Hafize Uzun |
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| Přispěvatelé: | Acibadem University Dspace, İÜC, Cerrahpaşa Tıp Fakültesi, Temel Tıp Bilimleri Bölümü |
| Rok vydání: | 2020 |
| Předmět: |
Male
cancer patient Cachexia Lung Neoplasms very elderly medicine.medical_treatment cisplatin body weight change etoposide Gastroenterology chemoradiotherapy lung tumor Body Mass Index paclitaxel Weight loss Carcinoma Non-Small-Cell Lung middle aged advanced cancer Medicine Prospective Studies pemetrexed Aged 80 and over C reactive protein biology adult digestive oral and skin physiology Cancer cachexia General Medicine Chemoradiotherapy Middle Aged Prognosis Ghrelin aged female C-Reactive Protein Oncology human serum albumin anorexia carboplatin blood sampling Female albumin blood level medicine.symptom prospective study medicine.medical_specialty Serum albumin Serum Albumin Human Article multiple cycle treatment locally advanced nonsmall cell lung cancer blood Internal medicine vinblastine cancer combination chemotherapy cancer radiotherapy Humans Radiology Nuclear Medicine and imaging human Lung cancer albumin Aged non small cell lung cancer business.industry Cancer medicine.disease major clinical study body mass Radiation therapy Concomitant biology.protein pathology business metabolism |
| Zdroj: | Journal of cancer research and therapeutics. 16(4) |
| ISSN: | 1998-4138 |
| Popis: | PubMed: 32930130 Background: Ghrelin plays a role in mechanisms related to cancer progression - including cell proliferation, invasion and migration, and resistance to apoptosis in the cell lines from several cancers. We investigated the role of ghrelin levels in cancer cachexia-anorexia in patients with locally advanced nonsmall-cell lung cancer (NSCLC) treated with chemoradiotherapy (CRT). Materials and Methods: This study involved 84 NSCLC patients who had received concomitant CRT. Blood ghrelin levels were compared before and 3 months after CRT. Meanwhile, changes in body weight of the patients were also investigated with changes in ghrelin levels before and after CRT. Results: Ghrelin levels were significantly decreased in line with changes in patients' weights in patients receiving CRT (P < 0.001). Serum albumin levels and inflammatory-nutritional index were significantly decreased after radiotherapy (RT) (3.01 ± 0.40 g/dL, 0.38 ± 0.20) when compared with its baseline levels (3.40 ± 0.55 g/dL,P < 0.001; 0.86 ± 0.71,P < 0.001, respectively). Serum C-reactive protein levels were significantly increased after CRT (7.49 ± 6.53 mg/L) when compared with its baseline levels (9.54 ± 3.80 mg/L,P = 0.038). After RT, ghrelin levels in patients were positively correlated with body mass index (r = 0.830,P < 0.001) and albumin (r = 0.758,P < 0.001). Conclusion: Ghrelin may play a role in the pathogenesis of weight loss in NSCLC patients. Ghrelin seems to be implicated in cancer-related weight loss. Ghrelin, cancer, and RT all together have a role in tumor-related anorexia-cachexia in patients with NSCLC. Results of this study need further evaluation as regards to its potential role as an adjuvant diagnostic or prognostic marker. © 2020 Wolters Kluwer Medknow Publications. All rights reserved. |
| Databáze: | OpenAIRE |
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