A Deletion of Mitochondrial DNA in Murine Doxorubicin-Induced Cardiotoxicity
| Autor: | Yuji Sugiu, Hironori Toshima, Kyo Adachi, Toshihiko Sakanashi, Fujiura Y, Akira Nozuhara, Mayumi F, T. Hidaka |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Mitochondrial DNA Molecular Sequence Data Biophysics Mitochondrion Biology medicine.disease_cause DNA Mitochondrial Polymerase Chain Reaction Thiobarbituric Acid Reactive Substances Biochemistry Mitochondria Heart Mice chemistry.chemical_compound polycyclic compounds medicine Animals Doxorubicin Molecular Biology Heart metabolism Sequence Deletion Coenzyme Q10 Mice Inbred BALB C Cardiotoxicity Mutation Base Sequence Myocardium Heart Cell Biology Molecular biology Oligodeoxyribonucleotides chemistry DNA medicine.drug |
| Zdroj: | Biochemical and Biophysical Research Communications. 195:945-951 |
| ISSN: | 0006-291X |
| DOI: | 10.1006/bbrc.1993.2135 |
| Popis: | A deletion of about 4 kb has been determined in the mutated mitochondrial DNA (mtDNA) in cardiomyocytes with chronic doxorubicin (DOX)-induced cardiotoxicity in mouse. The incidence of the mtDNA deletion increased with the dosage and with the duration of the DOX administration. Coenzyme Q10 administration prevented the mtDNA deletion and decreased the thiobarbituric acid reactive substance content in the heart mitochondria, suggesting some free radical involvement in this mtDNA deletion. This mtDNA deletion may be involved in cardiomyopathy, which is known to be dosage-dependently induced by DOX administration. |
| Databáze: | OpenAIRE |
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