Predicting cardiac autonomic neuropathy in type I (insulin-dependent) diabetes mellitus
| Autor: | P. L. Rohatsch, Dennis L. Fung, T. T. Aoki, E. A. Disbrow, R. S. Jaffe |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Sympathetic nervous system Supine position Electrocardiography Parasympathetic nervous system Diabetic Neuropathies Heart Rate Parasympathetic Nervous System Internal medicine Diabetes mellitus Heart rate medicine Humans Heart rate variability Sample variance Diabetic Retinopathy Fourier Analysis Endocrine and Autonomic Systems business.industry Diabetic retinopathy medicine.disease Diabetes Mellitus Type 1 Endocrinology medicine.anatomical_structure Autonomic Nervous System Diseases Cardiology Regression Analysis Female Neurology (clinical) Nervous System Diseases business Forecasting |
| Zdroj: | Clinical Autonomic Research. 5:155-158 |
| ISSN: | 1619-1560 0959-9851 |
| DOI: | 10.1007/bf01826198 |
| Popis: | A total of 24 subjects with type I insulin-dependent diabetes mellitus were studied. Cardiac parasympathetic function was measured by supine heart rate variability (HRV) in the respiratory frequency 0.10-0.50 Hz and the sympathetic index was measured as the ratio of HRV between 0.055 and 0.098 Hz to that between 0.004 and 0.5 Hz. Factors assessing diabetic control and complications, and factors unrelated to diabetes but possibly influencing HRV, were recorded. Association with depressed HRV was assessed with correlation, and prediction of depressed HRV was determined with multiple regression. Factors associated with depressed HRV but not independently predictive were renal dysfunction and elevated thyroid stimulating hormone. Elevated glycosylated haemoglobin was not significantly correlated with depressed HRV. Four factors (presence of diabetic retinopathy, male gender, duration of diabetes and increasing age) were significant in the regression and sufficed to predict 81% of the sample variance. The relative weights (beta) were -0.65, 0.40, -0.40 and 0.26, respectively. Supine sympathetic index was not sufficient to demonstrate sympathetic dysfunction. It is proposed that the regression model may be used to identify patients likely to have cardiac parasympathetic autonomic dysfunction. |
| Databáze: | OpenAIRE |
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