Correlation of vitamin D receptor gene (ApaI) polymorphism with periodontitis: A meta‐analysis of Chinese population
| Autor: | Hai‐xia Guo, Si‐jia Cui, Jian Pan, Heng‐biao Pan, Chun‐ying Fang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty lcsh:TX341-641 Subgroup analysis Lower risk Calcitriol receptor polymorphism VDR ApaI 03 medical and health sciences 0302 clinical medicine Polymorphism (computer science) Internal medicine periodontitis meta‐analysis medicine Original Research Periodontitis business.industry 030206 dentistry Odds ratio medicine.disease Confidence interval 030104 developmental biology Meta-analysis business lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Food Science & Nutrition, 7(11):3607-3612 Food Science & Nutrition, Vol 7, Iss 11, Pp 3607-3612 (2019) Food Science & Nutrition |
| ISSN: | 2048-7177 |
| Popis: | Many studies have tried to elucidate the connection between vitamin D receptor (VDR) gene (ApaI) polymorphism and periodontitis; however, so far there is no consensus. To further assess the impact of ApaI polymorphism on periodontitis risk, we have conducted a meta‐analysis of Chinese population. Relevant literatures were searched according to PubMed and Chinese database in January 2019. The strength of correlation was evaluated by combining odds ratio (ORs) and 95% confidence interval (CIs). Six case–control studies were identified with inclusion criteria, including 734 cases of periodontitis and 687 controls. Based on the overall analysis, the VDR ApaI polymorphism was not due to the risk of periodontitis in all models. Subgroup analysis showed that the risk of periodontitis in North China was significantly reduced. To sum up, the study shows that VDR‐ApaI polymorphism may be connected with a lower risk of periodontitis in northern China. It is suggested that inferential studies should be conducted in other ethnic groups. |
| Databáze: | OpenAIRE |
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