Influence of genetic substructuring of statistical forensic parameters on genetic short tandem repeat markers in the populations of Southeastern Europe

Autor: Novokmet, Natalija, Peričić Salihović, Marijana, Škaro, Vedrana, Projić, Petar, Šarac, Jelena, Havaš Auguštin, Dubravka, Rudan, Pavao, Primorac, Dragan, Marjanović, Damir
Rok vydání: 2022
Předmět:
Zdroj: Croatian Medical Journal
Volume 63
Issue 3
ISSN: 1332-8166
0353-9504
DOI: 10.3325/cmj.2022.63.244
Popis: Aim To investigate the influence of specific intrapopula - tion genetic structures on interpopulation relationships. Special focus was the influence of island population isola - tion on the substructuring of the Croatian population, and the influence of regional population groups on the sub - structuring of Southeast European populations. Methods Autosomal short tandem repeat (STR) loci were analyzed by using four forensic parameters: matching probability (PM), power of discrimination (PD), power of exclusion (PE), and polymorphic information content (PIC) on a sample of 2877 unrelated participants of both sexes. A sample set comprising 590 participants was analyzed for the first time, and 2287 participants were included from previous studies. The analysis was performed with Power - Stats v. 1.2. Results The analysis of forensic parameters for all nine loci in the Croatian subpopulations showed the largest devia - tions in the populations of the islands of Korčula and Hvar. The smallest deviations were found in the mainland popu - lation. As for Southeast European populations, the largest deviations were found in the population of North Mace - donia, followed by Romania, Albanians from Kosovo, and Montenegro, while the smallest deviations were found in the population of Hungary. Conclusion The comparison of forensic parameters be - tween different subpopulations of Croatia and Southeast Europe indicates that the isolation of individual Croatian subpopulations and rare alleles in their gene pool affect the values of forensic parameters. Specific features of (sub) populations should be taken into account for appropriate sampling of the total population when creating a DNA da - tabase of STR markers.
Databáze: OpenAIRE
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