Complement activation in Lyme neuroborreliosis--increased levels of C1q and C3a in cerebrospinal fluid indicate complement activation in the CNS
| Autor: | Dag Nyman, Sten-Anders Carlsson, Kristina Nilsson Ekdahl, Christian Jansson, Pia Forsberg, Kerstin Sandholm, Anna J. Henningsson, Hans Granlund, Jan Ernerudh |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Central Nervous System Male Pathology medicine.medical_specialty Adolescent Immunology Inflammation Enzyme-Linked Immunosorbent Assay Statistics Nonparametric Classical complement pathway Cerebrospinal fluid Immune system medicine Immunology and Allergy Humans Lyme Neuroborreliosis Child Complement Activation Aged Aged 80 and over business.industry Complement C1q Complement C3 Middle Aged medicine.disease Complement (complexity) Complement system Neurology Child Preschool Female Neurology (clinical) medicine.symptom business Neuroborreliosis |
| Zdroj: | Journal of neuroimmunology. 183(1-2) |
| ISSN: | 0165-5728 |
| Popis: | A strong initial inflammatory response is important in neuroborreliosis. Since complement is a main player in early inflammation, we monitored the concentration and activation of complement in plasma and cerebrospinal fluid from 298 patients, of whom 23 were diagnosed with neuroborreliosis. Using sandwich ELISAs, we found significantly elevated levels of C1q, C4, C3, and C3a in cerebrospinal fluid, but not in plasma, in patients with neuroborreliosis. This finding indicates that complement plays a role in the human immune response in neuroborreliosis, that the immunologic process is compartmentalized to the CNS, and that complement activation may occur via the classical pathway. |
| Databáze: | OpenAIRE |
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