Identification of evodiamine as the bioactive compound in evodia (Evodia rutaecarpa Benth.) fruit extract that activates human peroxisome proliferator-activated receptor gamma (PPARγ)
| Autor: | John F. Rebhun, Rodney A. Velliquette, Samantha J Roloff, Stephen R. Missler |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
MAPK/ERK pathway
Evodiamine Peroxisome proliferator-activated receptor CHO Cells Pharmacology Rutaecarpine Mass Spectrometry Evodia Indole Alkaloids Evodia rutaecarpa Benth chemistry.chemical_compound Troglitazone Cricetulus Drug Discovery Animals Humans Peroxisome proliferator-activated receptor gamma Chromans Receptor Chromatography High Pressure Liquid chemistry.chemical_classification Molecular Structure Plant Extracts General Medicine Hep G2 Cells Peroxisome Bioactive compound PPAR gamma chemistry Phytochemical Biochemistry Fruit Quinazolines Thiazolidinediones Evodia fruit extract |
| Zdroj: | Fitoterapia. 101 |
| ISSN: | 1873-6971 |
| Popis: | The dried unripe fruit from Evodia rutaecarpa Benth., known as Wu zhu yu in China, has long been used in traditional Chinese medicine. In this research, we provide evidence that evodia fruit extract activates peroxisome proliferator-activated receptor gamma (PPARγ) and, as identified through HPLC fractionation and mass spectroscopy, the activating phytochemical is evodiamine. Evodiamine was shown to bind to and activate PPARγ. It was also shown to activate PPARγ-regulated gene expression in human hepatoma cells similar to known PPARγ ligands and that the expression was blocked by a PPARγ specific antagonist. |
| Databáze: | OpenAIRE |
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