Incorporation of the Nonproteinogenic Amino Acid β-Methylamino-alanine Affects Amyloid β Fibril Properties and Toxicity
| Autor: | Daniel Huster, Corinna Höfling, Steffen Roßner, Alexander Korn, Martin Krueger, Ulrike Zeitschel |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Amyloid
Amyloid β Cell Survival Physiology Cognitive Neuroscience Neurotoxins Fibril Biochemistry 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Humans Neurotoxin Amino Acid Sequence Risk factor Cytoskeleton 030304 developmental biology chemistry.chemical_classification Alanine 0303 health sciences Amyloid beta-Peptides Potential risk Amino Acids Diamino Cell Biology General Medicine Amino acid chemistry Toxicity 030217 neurology & neurosurgery |
| Zdroj: | ACS Chemical Neuroscience. 11:1038-1047 |
| ISSN: | 1948-7193 |
| DOI: | 10.1021/acschemneuro.9b00660 |
| Popis: | The nonproteinogenic amino acid β-methylamino alarelevant example for environmental hazards are nonnine (BMAA) is a neurotoxin and represents a potential risk factor for neurodegenerative diseases. Despite intense research over the last years, the pathological mechanism of BMAA is still unclear. One of the main open questions is whether BMAA can be misincorporated into proteins, especially as a substitute for serine, and whether this has structural and functional consequences for the afflicted proteins leading to early onset neurodegeneration. In this study, we hypothesize that BMAA was indeed incorporated into Aβ |
| Databáze: | OpenAIRE |
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