Cutting edge : IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2
| Autor: | Sergei V. Kotenko, Shubha Anantha, Nital K. Shah, Harold Dickensheets, Vitaliy V. Baurin, Jean-Christophe Renauld, Faruk Sheikh, Alexander Zdanov, Raymond P. Donnelly, Sergey V. Smirnov, Anita Lewis-Antes, Laure Dumoutier |
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| Přispěvatelé: | UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique |
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
STAT3 Transcription Factor
Receptor complex DNA-Binding Proteins - metabolism Immunology B-cell receptor Biology Cell Line Organ Specificity - genetics immunology Interleukin 26 Cell Line Tumor Immunology and Allergy Protein Isoforms Humans 5-HT5A receptor Receptors Interleukin-10 GABBR2 Receptor Signal Transduction - immunology Interleukins Receptors Interleukin - biosynthesis genetics physiology Receptors Interleukin Interleukin-13 receptor Cell biology Interleukin-10 Interleukin-10 - metabolism DNA-Binding Proteins Interleukin 10 STAT1 Transcription Factor Organ Specificity Trans-Activators - metabolism Protein Isoforms - biosynthesis genetics physiology Trans-Activators Interleukins - metabolism physiology Dimerization HT29 Cells Signal Transduction |
| Zdroj: | Journal of immunology (Baltimore, Md. : 1950), Vol. 172, no. 4, p. 2006-2010 (2004) |
| Popis: | The receptor for IL-26 (AK155), a cytokine of the IL-10 family, has not previously been defined. We demonstrate that the active receptor complex for IL-26 is a heterodimer composed of two receptor proteins: IL-20R1 and IL-10R2. Signaling through the IL-26R results in activation of STAT1 and STAT3 which can be blocked by neutralizing Abs against IL-20R1 or IL-10R2. IL-10R2 is broadly expressed on a wide variety of tissues, whereas only a limited number of tissues express IL-20R1. Therefore, the ability to respond to IL-26 is restricted by the expression of IL-20R1. IL-10, IL-19, IL-20, IL-22, and IL-24 fail to signal through the combination of IL-10R2 and IL-20R1 proteins, demonstrating that this receptor combination is unique and specific for IL-26. |
| Databáze: | OpenAIRE |
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