Evaluation of oxidant-antioxidant balance in patients on maintenance haemodialysis: a comparative study of dialyzers membranes
| Autor: | Juan F, Macías Núñez, Zoubiair, Ghais, Jesus, Bustamante, Jose M, Lopez-Novoa, J, Arrieta, G, Barril, María D, Del Pino, C, Escaja, I M, Martín, C, Fernández Andrade, F, García, J, Núñez, J M, Onaindía, J, González, M, Pérez-Prieto, M, Fernández, J, Lopez, J M, Santiago, M, Vicens, F, Sousa |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Antioxidant medicine.medical_treatment Comorbidity End stage renal disease Superoxide dismutase Renal Dialysis Internal medicine Extracellular Medicine Humans Serum Albumin Aged chemistry.chemical_classification Cellulose diacetate biology business.industry Superoxide Dismutase Albumin Transferrin Membranes Artificial General Medicine Equipment Design Middle Aged Oxidative Stress Membrane Endocrinology C-Reactive Protein chemistry Nephrology biology.protein Kidney Failure Chronic Female business beta 2-Microglobulin |
| Zdroj: | Nephron. Clinical practice. 114(1) |
| ISSN: | 1660-2110 |
| Popis: | Background: Haemodialysis (HD) exacerbates oxidative stress (OS). The polymethyl-methacrylate (PMMA)-BK-F membrane ameliorates OS and inflammation markers compared to polyacrylonitrile (PAN/AN69) and cellulose membranes. This may be due to the size of pore radius, high flux or other specific properties of PMMA membranes. Aim: To compare OS and inflammatory status in HD-treated end stage renal disease patients with membranes of different pore size radius and flux. Methods: 47 patients of both sexes were studied. The HD membranes with which the patients were normally treated were changed to BK-P or B-3 membranes for 6 months. Intracellular and extracellular components of the oxidant-antioxidant balance (OAB), C-reactive protein (CRP), β2-micro-globulin (β2µ-globulin), albumin and transferrin were measured. Results: A significant decrease in red cell membrane thiobarbituric acid reacting substances and an increase in cytosolic superoxide dismutase (SOD) and plasma total antioxidant substances were observed in all patients after 6 months of treatment with BK-P and B-3 membranes except SOD and CRP in patients previously dialysed with triacetate cellulose membranes. Albumin and transferrin remained unmodified. β2µ-globulin significantly decreased after treatment with PMMA membranes. Conclusion: BK-P and B-3 HD membranes improved the OAB, β2µ-globulin and CRP compared to PAN/AN69 and cellulose diacetate membranes. |
| Databáze: | OpenAIRE |
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