Plasma aldosterone levels and development of insulin resistance: prospective study in a general population
| Autor: | Eri Tsukagawa, Yasuki Nanjo, Ako Fukami, Maki Otsuka, David R. Jacobs, Hisashi Adachi, Kanako Yokoi, Yuji Hirai, Kinuka Ogata, Kuniko Yoshikawa, Akiko Kasahara, Shun Ichi Kumagae, Tsutomu Imaizumi, Eishi Esaki, Eita Kumagai, Kyoko Ohbu-Murayama, Mika Enomoto |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Alcohol Drinking Cross-sectional study medicine.medical_treatment Population Posture chemistry.chemical_compound Insulin resistance Japan Predictive Value of Tests Risk Factors Internal medicine Internal Medicine Medicine Humans Prospective Studies education Prospective cohort study Aldosterone Aged Aged 80 and over education.field_of_study business.industry Insulin Confounding Smoking Middle Aged medicine.disease Endocrinology Cross-Sectional Studies chemistry Hypertension Potassium Female Insulin Resistance business Homeostasis Follow-Up Studies |
| Zdroj: | Hypertension (Dallas, Tex. : 1979). 58(6) |
| ISSN: | 1524-4563 |
| Popis: | Aldosterone plays a role in hypertension, and hypertension is prevalent in patients with insulin resistance. Cross-sectional studies have reported that plasma aldosterone levels are higher in patients with insulin resistance. However, it is not known whether plasma aldosterone levels predict the development of insulin resistance. Subjects of the present study were 1235 local residents (490 men and 745 women) who participated in health screenings in Japan in 1999. Plasma aldosterone levels were measured by radioimmunoassay. We investigated the cross-sectional relationship between plasma aldosterone levels and insulin resistance (homeostasis model assessment index ≥1.73 according to the diagnostic criteria used in Japan) in 1088 nondiabetic participants. At the 10-year follow-up, 141 subjects had died, and 260 subjects refused re-examination. We performed a prospective analysis of 564 subjects to predict incident insulin resistance. We found a significant ( P P |
| Databáze: | OpenAIRE |
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