Factors affecting the progression of diabetic nephropathy and its complications: A single-center experience in Saudi Arabia
| Autor: | Arthur C. Isnani, Ali Al-Harbi, Mohammed Al Ghonaim, Shaffi Ahmed Shaikh, Jamal Al-Wakeel, Abdulkareem Alsuwaida, Sulaiman Almohaya |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Saudi Arabia Renal function 030209 endocrinology & metabolism Disease urologic and male genital diseases Single Center Diabetic nephropathy 03 medical and health sciences 0302 clinical medicine Risk Factors Diabetes mellitus Internal medicine Humans Medicine Diabetic Nephropathies 030212 general & internal medicine Intensive care medicine Aged Retrospective Studies Aged 80 and over business.industry Disease progression Retrospective cohort study General Medicine Middle Aged medicine.disease Proteinuria Diabetes Mellitus Type 2 Creatinine Disease Progression Kidney Failure Chronic Original Article Female Creatinine blood business Biomarkers Glomerular Filtration Rate |
| Zdroj: | Annals of Saudi Medicine |
| ISSN: | 0975-4466 0256-4947 |
| DOI: | 10.4103/0256-4947.81528 |
| Popis: | BACKGROUND AND OBJECTIVES: One out of five Saudi diabetics develops end-stage renal disease (ESRD). Factors associated with progressive loss of renal function have not been extensively studied and reported in our community. We sought to evaluate the pattern and progression in glomerular filtration rate (GFR) and investigate the potential risk factors associated with progression to diabetic nephropathy (DN) among Saudi patients. DESIGN AND SETTING: Hospital-based retrospective analysis of type 2 diabetic patients seen between January 1989 and January 2004 at Security Forces Hospital and King Saud University in Riyadh, Saudi Arabia. PATIENTS AND METHODS: DN was defined as persistent proteinuria assessed by urine dipstick [at least twice for at least two consecutive years and/or serum creatinine >130 μmol/L; and/or GFR 90 mL/min/1.73m2 at the first hospital visit; duration of diabetes >10 years; persistent proteinuria; systolic blood pressure >130 mm Hg; and presence of retinopathy were significant markers associated with progression of nephropathy. CONCLUSION: Diabetic nephropathy tends to be progressive among Saudis, with GFR deteriorating at a rate of 3.3 mL/year and with a doubling of serum creatinine level in 40.3% of patients in 9.9 years. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|