Primary Pituitary Adenoid Cystic Carcinoma: A Rare Salivary Gland-Like Tumor in the Sella
| Autor: | Motohiro Morioka, Jin Kikuchi, Kiyohiko Sakata, Motohisa Koga, Jun Akiba, Takeharu Ono, Satoru Komaki, Yasuo Sugita, Etsuyo Ogo, Hirohito Umeno |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pituitary gland Pathology medicine.medical_specialty Adenoma Adenoid cystic carcinoma Case Reports behavioral disciplines and activities Pathology and Forensic Medicine Diagnosis Differential 03 medical and health sciences 0302 clinical medicine stomatognathic system Major Salivary Gland medicine Biomarkers Tumor Humans Pituitary Neoplasms Aged Salivary gland business.industry medicine.disease Primary tumor Carcinoma Adenoid Cystic Magnetic Resonance Imaging stomatognathic diseases 030104 developmental biology medicine.anatomical_structure Sella turcica Oncology Otorhinolaryngology 030220 oncology & carcinogenesis Cavernous sinus Female business Tomography X-Ray Computed |
| Zdroj: | Head Neck Pathol |
| ISSN: | 1936-0568 |
| Popis: | Adenoid cystic carcinoma (ACC) is a tumor of the exocrine glands that originates primarily from the minor and major salivary glands, nasopharynx, and lacrimal glands. ACC grows slowly but is locally aggressive and prone to recurrence. It is uncommon for ACCs to develop in the pituitary gland as a primary tumor. We present a case of primary pituitary ACC extending to the sphenoid sinus resembling an invasive adenoma in a 71-year-old woman with a history of nasal epistaxis. We reviewed other reported cases of pituitary ACCs with retrospective validation of whether the tumor was primary or not. The intrasellar tumor exhibited MYB rearrangement with enlargement and destruction of the sella turcica and dural tears toward the sphenoid sinus, which would be consistent for a tumor originating from the pituitary gland. Including our case, only four intrasellar and one suprasellar ACC have been confirmed as primary tumors. All intrasellar ACCs had the characteristic of some form of invasion of neighboring structures with evidence of hyperprolactinemia. ACC could develop in the pituitary gland as a form of salivary gland-like tumor derived from the ectopic salivary gland rests. ACCs rarely arise from the pituitary gland; however, the accurate determination of primary occurrence is difficult because of the invasive nature of these tumors, and the anatomical relationship with the sphenoid sinus and the cavernous sinus. Excessive bleeding from the tumor or unexpected internal carotid artery injury should be avoided during surgery for primary and secondary pituitary ACC. |
| Databáze: | OpenAIRE |
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