Safety of Brucella abortus Strain RB51 in Deer Mice
| Autor: | Sharon K. Taylor, Sandra Anderson, E. Tom Thorne, Elizabeth S. Williams, Walter E. Cook |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Veterinary medicine Peromyscus medicine.medical_treatment Colony Count Microbial Administration Oral Brucella Vaccine Brucella abortus Biology complex mixtures Brucellosis Bison bison Random Allocation medicine Animals symbols.heraldic_charge Saline Ecology Evolution Behavior and Systematics Colony-forming unit Brucellosis vaccine Ecology Strain (chemistry) Inoculation Uterus medicine.disease biology.organism_classification symbols Female Safety Injections Intraperitoneal Spleen |
| Zdroj: | Journal of Wildlife Diseases. 37:621-625 |
| ISSN: | 0090-3558 |
| DOI: | 10.7589/0090-3558-37.3.621 |
| Popis: | Brucella abortus strain RB51 is an approved brucellosis vaccine for use in cattle that may have potential as an oral vaccine for use in elk (Cervus elaphus) and/or bison (Bison bison). This study was designed to determine effects of strain RB51 on deer mice (Peromyscus maniculatus), a nontarget species that could have access to treated baits in a field situation. In February 1994, 90 mice were orally dosed or intraperitoneally injected with 1 x 10(8) colony forming units strain RB51 and 77 controls were similarly dosed with sterile saline. At weekly intervals through early April 1994, 4 to 6 mice from each group were euthanized, gross necropsies performed, spleens and uteruses cultured, and tissues examined histologically. All orally inoculated mice cleared the infection by 6 wk post-inoculation (PI). While most of the injected mice cleared the infection by 7 wk PI, a few required 9 wk. There were minimal adverse effects attributable to strain RB51. Apparently, strain RB51 would not negatively impact P. maniculatus populations if it were used in a field situation. Also, deer mice appear to be able to clear the vaccine in 6 to 9 wk, thus the probability of these mice transmitting the vaccine to other animals is low. |
| Databáze: | OpenAIRE |
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