P50 sensory gating in adolescents from a pacific island isolate with elevated risk for schizophrenia
| Autor: | Francisca Blailes, Lisa M. Ord, Marina Myles-Worsley, Robert Freedman, Hilda Ngiralmau |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Risk medicine.medical_specialty Psychosis Native Hawaiian or Other Pacific Islander Adolescent Offspring Palau Gating Audiology Prodrome Schizotypal Personality Disorder medicine Reaction Time Humans Attention Genetic Predisposition to Disease Risk factor Biological Psychiatry Auditory Cortex Psychiatric Status Rating Scales Sensory gating Electroencephalography Neural Inhibition Signal Processing Computer-Assisted medicine.disease medicine.anatomical_structure Genetics Population Phenotype Schizophrenia Endophenotype Evoked Potentials Auditory Female Schizophrenic Psychology Psychology Neuroscience |
| Zdroj: | Biological psychiatry. 55(7) |
| ISSN: | 0006-3223 |
| Popis: | Background Gating or inhibition of the P50 auditory evoked potential is a heritable neurobiological trait that has shown strong potential to serve as an endophenotype for schizophrenia. P50 sensory gating deficits have been found repeatedly in schizophrenic patients and in their unaffected first-degree relatives. P50 sensory gating has not yet been studied in high-risk (HR) offspring nor in prodromal adolescents. Methods A paired-stimulus auditory event-related potential paradigm was used to examine P50 sensory gating in 44 genetically HR adolescent offspring and 43 clinically HR prodromal adolescents with the same low genetic liability as a comparison group of 39 normal adolescents. Results Auditory sensory gating, as measured by the P50 ratio, was impaired in both genetically HR offspring and also in the clinically HR prodromal adolescents with no close affected relatives. In the genetically HR group, abnormal P50 sensory gating was found only in offspring who met criteria for the schizophrenia prodrome. Conclusions Our findings suggest that P50 deficits are associated with the presence of prodromal symptoms, regardless of genetic risk. The results are consistent with the hypothesis that genetic liability in HR offspring increases risk for prodromal symptoms, and prodromal symptoms, in turn, increase risk for impaired sensory gating. |
| Databáze: | OpenAIRE |
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