Seasonal exacerbation of esophageal eosinophilia in children with eosinophilic esophagitis and allergic rhinitis
| Autor: | Antonella Cianferoni, Ritu Verma, Gita Ram, Jonathan M. Spergel, Michele Shuker, Juhee Lee, Terri F. Brown-Whitehorn, Chris A. Liacouras, Megan T. Ott, Mei-Lun Wang |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Exacerbation Immunology Esophagus Eosinophilia Biopsy medicine Humans Immunology and Allergy Child Eosinophilic esophagitis Retrospective Studies Asthma Inhalation Exposure medicine.diagnostic_test business.industry Retrospective cohort study Eosinophilic Esophagitis Allergens Eosinophil medicine.disease Rhinitis Allergic Dermatology Eosinophils medicine.anatomical_structure Disease Progression Female Seasons medicine.symptom business |
| Zdroj: | Annals of Allergy, Asthma & Immunology. 115:224-228.e1 |
| ISSN: | 1081-1206 |
| DOI: | 10.1016/j.anai.2015.07.004 |
| Popis: | Background Evidence supports a possible link between eosinophilic esophagitis (EoE) and environmental aeroallergens, which can manifest as seasonal exacerbation of esophageal eosinophilia. Few studies have examined this link in pediatric patients with EoE. Objective To identify the proportion of patients with seasonal induced esophageal eosinophilia. Methods A retrospective chart review was conducted of all patients diagnosed with EoE at the authors' institution. Demographic data were collected by chart review. Seasonal variation or flare was defined as a change from fewer than to at least 15 eosinophils per high-power field and a minimum of a 2-fold increase in eosinophil count between 2 consecutive biopsy specimens in different seasons without dietary or medication modifications. Results Of the 1,180 patients with EoE, 160 (14%) were suspected of having aeroallergen-associated triggers by history. Of these 160 patients, 32 (20%) had biopsy examination-confirmed variation of EoE triggered by aeroallergens. Most of these patients were boys (84%), all had a history or examination consistent with allergic rhinitis, and most had a history of asthma (75%). Thirty-two subjects had obvious seasonal variation, 22 of whom also had known food-induced symptoms. Conclusion Children with EoE and allergic rhinitis might have exacerbations in their esophageal eosinophilia during certain seasons depending on the specific aeroallergens to which they are sensitized. Identification of environmental allergens to sensitized patients is important and can guide therapy. |
| Databáze: | OpenAIRE |
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