Abscess scintigraphy with 99mTc-human immunoglobulin (IgG) using a one-step labeling method
| Autor: | Z. H. Oster, George E. Meinken, Cora J. Cabahug, Gene-Jack Wang, D.F. Sacker, Christopher Wong, Peter M. Som, B.A. Rhodes |
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| Rok vydání: | 1993 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Metabolic Clearance Rate Turpentine Immunoglobulins chemistry.chemical_element Kidney Technetium Scintigraphy Immunoglobulin G Mice Dogs Glioma medicine Animals Tissue Distribution Radiology Nuclear Medicine and imaging Radionuclide Imaging Abscess Lung Escherichia coli Infections biology medicine.diagnostic_test business.industry Indium Radioisotopes Gamma globulin Neoplasms Experimental medicine.disease Rats Inbred F344 Rats chemistry Mice Inbred CBA biology.protein Molecular Medicine Female Rabbits Sarcoma Experimental business Technetium-99m |
| Zdroj: | Nuclear Medicine and Biology. 20:225-230 |
| ISSN: | 0969-8051 |
| DOI: | 10.1016/0969-8051(93)90119-f |
| Popis: | It was shown earlier that non-specific human gamma globulin (IgG) labeled with 111In can be used as an agent for abscess localization. We describe experimental results with 99mTc-IgG in animals bearing abscesses and tumors using a one-step labeling method with 99mTc. We studied this compound in several animal models: mice bearing turpentine abscesses and subcutaneously transplanted sarcomas, in rats with turpentine or E. coli abscesses and intracerebrally implanted gliomas and in rabbits with E. coli or turpentine abscesses. Blood clearance was studied in dogs. It was found that the absolute concentration of 111In-IgG in abscess and tumor was higher than that of 99mTc-IgG. However, the abscess-to-tumor ratio was higher for 99mTc-IgG. The 99mTc-IgG images were of high quality and abscesses could be detected as early as 30 min post-injection (p.i.). It appears that 99mTc-IgG has many potential advantages over 111In-IgG because of better physical properties of 99mTc, simpler preparation, lower cost and greater availability and the possibility of using higher 99mTc doses. |
| Databáze: | OpenAIRE |
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