Estrogen Production and Its Origin in Men with Gonadotropin-Producing Neoplasms*
| Autor: | Frederick B. Cohen, Diana Jespersen, Marvin A. Kirschner |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Adult
Male medicine.medical_specialty Lung Neoplasms Estrone medicine.drug_class Endocrinology Diabetes and Metabolism Clinical Biochemistry Dehydroepiandrosterone Tritium Mediastinal Neoplasms Biochemistry Paraneoplastic Endocrine Syndromes chemistry.chemical_compound Endocrinology Dehydroepiandrosterone sulfate Testicular Neoplasms Stomach Neoplasms Internal medicine medicine Humans Choriocarcinoma Aged Estradiol Chemistry Stomach Biochemistry (medical) Middle Aged medicine.disease Primary tumor medicine.anatomical_structure Estrogen Hormones Ectopic Gonadotropin hormones hormone substitutes and hormone antagonists |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 39:112-118 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-39-1-112 |
| Popis: | Urinary estradiol production rates were found to be elevated in 6 consecutive men with gonadotropin-producing tumors (4 with choriocarcinoma, and 2 with ectopic gonadotropinproducing tumors of stomach and lung). The ranged from 63 to 605 μg/day (1½- to 15-fold elevated) and correlated with gonadotropin production and tumor mass. To determine the origin of the elevated E2, 3H dehydroepiandrosterone sulfate (DHEA-SO4) was given iv and its conversion to urinary E2 determined by reverse isotope methods. The transfer constant ranged from 0.5 to 11.0% and increased as the increased. Control cancer patients had ρ values of |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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