Neuropsychological function in adults after high dose fractionated radiation therapy of skull base tumors
| Autor: | M. Austin-Seymour, Marcia Urie, Barbara C. Fullerton, Pat McManus, Guila Glosser, John E. Munzenrider, Judy Adams |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Neurology medicine.medical_treatment Chondrosarcoma Skull Base Neoplasms Temporal lobe Mental Processes Neuropsychology Biopsy Chordoma medicine Humans Learning Radiology Nuclear Medicine and imaging Prospective Studies Psychomotor learning Chemotherapy Radiation medicine.diagnostic_test business.industry Brain Middle Aged Surgery Radiation therapy Skull medicine.anatomical_structure Oncology Multivariate Analysis Female Cranial Irradiation business Psychomotor Performance |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 38:231-239 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/s0360-3016(97)00099-0 |
| Popis: | Purposes: To evaluate the long term effects of high dose fractionated radiation therapy on brain functioning prospectively in adults without primary brain tumors. Methods and Materials: Seventeen patients with histologically confirmed chordomas and low grade chondrosarcomas of the skull base were evaluated with neuropsychological measures of intelligence, language, memory, attention, motor function and mood following surgical resection/biopsy of the tumor prior to irradiation, and then at about 6 months, 2 years and 4 years followin completion of treatment. None received chemotherapy. Results: In the patients without tumor recurrence or radiation necrosis, the were no indications of adverse effects on cognitive functioning in the post-acute through the lage stages after brain irradiation. Even in aptients who received doses of radiation up to 66 Cobalt Gy equivalent through nondiseased (temporal lobe) brain tissue, memory and cognitive functioning remaining stable for up to 5 years after treatment. A mild decline in psychomotor speed was seen in more than half of the patients, and motor slowing was related to high radiation doses in midline and temporal lobe brain structures. Conclusion : Results suggest that in adults, tolerance for focused radiation is relatively high in cortical brain structures. |
| Databáze: | OpenAIRE |
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