Diagnostic performance of influenza viruses and RSV rapid antigen detection tests in children in tertiary care
| Autor: | D.A.M.C. van de Vijver, Georgina I. Aron, Fleur M. Moesker, J.J.A. van Kampen, A.D.M.E. Osterhaus, Marion Koopmans, Pieter L. A. Fraaij, M. Schutten |
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| Přispěvatelé: | Virology, Pediatrics |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Time Factors 030106 microbiology Orthomyxoviridae Nasal Washings Respiratory Syncytial Virus Infections Respiratory syncytial virus Tertiary care Gastroenterology Sensitivity and Specificity Virus Article 03 medical and health sciences 0302 clinical medicine Antigen Predictive Value of Tests Virology Internal medicine Influenza Human Medicine Humans 030212 general & internal medicine Direct fluorescent antibody Antigens Viral biology business.industry Diagnostic Tests Routine Tertiary Healthcare Infant Newborn virus diseases Infant Paediatrics biology.organism_classification Confidence interval Influenza 3. Good health Infectious Diseases Predictive value of tests Child Preschool Rapid antigen detection tests Female business |
| Zdroj: | Journal of Clinical Virology, 79, 12-17. Elsevier Journal of Clinical Virology |
| ISSN: | 1873-5967 1386-6532 |
| Popis: | Highlights • The here studied rapid antigen detection test (RADT) BinaxNOW RSV has a high sensitivity and positive predictive value. • RADT BinaxNOW Influenza A&B has a relatively low sensitivity and positive predictive value. • We advise a restricted use of RADT BinaxNOW Influenza A&B in a tertiary paediatric care setting. Background Rapid antigen detection tests (RADTs) are increasingly used to detect influenza viruses and respiratory syncytial virus (RSV). However, their sensitivity and specificity are a matter of debate, challenging their clinical usefulness. Objectives Comparing diagnostic performances of BinaxNow Influenza AB® (BNI) and BinaxNow RSV® (BNR), to those of real-time reverse transcriptase PCR (RT-PCR), virus isolation and direct immunofluorescence (D-IF) in paediatric patients. Study design Between November 2005 and September 2013, 521 nasal washings from symptomatic children (age |
| Databáze: | OpenAIRE |
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