The correlations of glycated hemoglobin and carbohydrate metabolism parameters with heart rate variability in apparently healthy sedentary young male subjects

Autor: Victoria Serhiyenko, Orest Abrahamovych, Andriy Cherkas, Sergii Golota, Armen Nersesyan, Peter Eckl, Neven Zarkovic, Christoph Pichler, Siegfried Knasmüller
Jazyk: chorvatština
Rok vydání: 2015
Předmět:
Blood Glucose
Male
LF
the power of low frequency oscillations
RMSSD
square root of the mean squared differences of successive RR intervals
ANS
autonomous nervous system
BMI
body mass index
Clinical Biochemistry
Disease
Biochemistry
Body Mass Index
pNN50
percentage of differences between adjacent normal RR intervals exceeding 50 milliseconds
sedentary lifestyle
glycated hemoglobin
heart rate variability
insulin sensitivity
correlations
Electrocardiography
chemistry.chemical_compound
Glycated hemoglobin
IR
insulin resistance
Heart Rate
HBA1c
glycated hemoglobin
Insulin
Medicine
Heart rate variability
TP
total power of RR-intervals oscillations
lcsh:QH301-705.5
SAN
sinoatrial node
Young male
2. Zero hunger
lcsh:R5-920
SDNN
standard deviation of normal RR intervals
HR
heart rate
HOMA
homeostatic model assessment
Insulin sensitivity
Carbohydrate Metabolism
lcsh:Medicine (General)
Research Paper
Adult
medicine.medical_specialty
FBG
fasting blood glucose
Sedentary lifestyle
Enzyme-Linked Immunosorbent Assay
HRV
heart rate variability
Carbohydrate metabolism
Young Adult
Diabetes mellitus
Internal medicine
Clinical Medical Sciences
Humans
Risk factor
Exercise
HSS
healthy sedentary subjects
Correlations
OT
orthostatic test
business.industry
Body Weight
Organic Chemistry
medicine.disease
VLF
the power of very low frequency oscillations
Endocrinology
lcsh:Biology (General)
chemistry
ECG
electrocardiogram
HF
the power of high frequency oscillations
CVS
cardiovascular system
business
Zdroj: Redox Biology
Redox Biology, Vol 5, Iss, Pp 301-307 (2015)
Popis: Introduction Sedentary lifestyle is a major risk factor for diabetes, cardiovascular and many other age-related diseases. Heart rate variability (HRV) reflects the function of regulatory systems of internal organs and may sensitively indicate early metabolic disturbances. We hypothesize that quantitative and qualitative changes of HRV in young subjects may reflect early metabolic derangements responsible for further development of clinically significant disease. Aim The aim of our study was to determine whether the parameters of carbohydrate metabolism (fasting blood glucose, HBA1c and surrogate insulin sensitivity/resistance indices) correlate with anthropometric data and HRV. Methods The study group consisted of 30 healthy sedentary male subjects aged 20–40, nonsmokers, mainly office and research employees, medical staff and students. Athletes, actively training more than one hour per week, severely obese and men of physical work were excluded from the study. HRV parameters were derived from short term ECG records (five minutes intervals) in supine position and during orthostatic test. Anthropometric data included height, weight, body mass index (BMI), age and body composition (estimation by bioelectric impedance method). The fasting blood glucose, insulin and C-peptide, homeostatic model assessment (HOMA-IR) index and glycated hemoglobin (HbA1c) were evaluated. Linear correlation coefficient (r) was calculated using Statistica 10.0 software. Results and discussion HOMA-IR index correlated positively with body weight, visceral fat and BMI (p=0.047, 0.027 and 0.017 respectively). In supine position pNN50 positively correlated with glucose/insulin ratio (p=0.011) and heart rate with HOMA-IR (p=0.006). In orthostatic test negative correlations of HBA1c with standard deviation, total and low frequency power were determined (p=0.034, 0.400 and 0.403 respectively), which indicates a gradual worsening of functional capacity of cardiovascular system with low-grade increase (under the conventional threshold) of HBA1c. Conclusions In apparently healthy sedentary subjects HRV reduction correlates with the age advancement, subclinical deteriorations of carbohydrate metabolism and excessive fat accumulation.
Graphical abstract
Highlights • Apparently healthy sedentary young male subjects were enrolled in the study. • HRV negatively correlates with age, BMI, visceral fat and insulin resistance. • Glycated hemoglobin negatively correlates with HRV parameters in orthostatic test. • Changes of HRV may reflect subclinical metabolic deteriorations in sedentary subjects.
Databáze: OpenAIRE
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