Cardiac β-receptor variation in rat strains selectively bred for differences in susceptibility to stress
| Autor: | Claud E. Dunlap, Bruce Liang, Lewis S. Freedman, David A. Blizard |
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| Rok vydání: | 1982 |
| Předmět: |
Male
medicine.medical_specialty Sympathetic Nervous System Chemistry Myocardium Rats Inbred Strains Locus (genetics) Sympathetic activity General Medicine General Biochemistry Genetics and Molecular Biology Rats Receptors Adrenergic β receptor Sympathetic stimulation Endocrinology Stress Physiological Internal medicine Receptors Adrenergic beta Dihydroalprenolol Radioligand medicine Animals General Pharmacology Toxicology and Pharmaceutics Negative correlation Receptor |
| Zdroj: | Life Sciences. 31:533-539 |
| ISSN: | 0024-3205 |
| Popis: | The radioligand 3 H-DHA was used to estimate the density and affinity of cardiac β-receptors in rat strains selectively bred for differences in response to stress. Maudsley Reactive rats selected for heightened reactivity to stress had a greater density of β-adrenergic binding in cardiac membranes than rats of two genetically distinct Maudsley Non-Reactive strains selected for decreased reactivity to stress, and compared with one of these Non-Reactive strains the MNR/Har, increased affinity for 3 H-DHA. Together with previous findings the present results demonstrate a negative correlation between estimates of basal sympathetic activity on the one hand, and post-synaptic β-receptors in heart on the other, that are consistent with the notion that these receptor alterations have occurred as a result of long-term differences in pre-synaptic release of transmitter. The Maudsley strains may, therefore, provide a useful model for the study of β-adrenergic receptors as a physiological locus for regulation of end-target responsiveness to sympathetic stimulation. |
| Databáze: | OpenAIRE |
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