AN EXPERIMENTAL STUDY OF PROTECTIVE INOCULATION WITH HEAT KILLED TUBERCLE BACILLI

Autor:	Jules Freund, Eugene L. Opie
Rok vydání:	1937
Předmět:	Bacillus (shape) Bacilli Tuberculosis biology Inoculation Tubercle business.industry Immunology biology.organism_classification medicine.disease Article Microbiology Vaccination Attenuated microorganism Antigen Immunology and Allergy Medicine business
Zdroj:	The Journal of Experimental Medicine
ISSN:	1540-9538 0022-1007
DOI:	10.1084/jem.66.6.761
Popis:	Heat killed tubercle bacilli repeatedly injected into or below the skin of rabbits increase conspicuously their resistance against infection with virulent tubercle bacilli. Protection against tuberculous infection following the administration of heat killed tubercle bacilli to rabbits is only slightly less than that given by BCG. Addition of certain antigens, notably heated horse serum, increases the protection given by heat killed tubercle bacilli so that it is approximately the same as that afforded by BCG. These experiments and tentative observations of persons exposed to tuberculous infection indicate that heat killed tubercle bacilli may be substituted for the living attenuated microorganism in the attempt to increase resistance against tuberculous infection and to influence favorably the delicate balance between asymptomatic or latent infection and progressive manifest disease that is characteristic of human tuberculosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94c9e3fe2b00211e64dc5ad20019c95a https://doi.org/10.1084/jem.66.6.761 Zobrazit plný text záznamu