Ointment is evenly spread on the skin, in contrast to creams and solutions
| Autor: | V. Tetens, U.I. Ivens, B. Steinkjer, Jørgen Serup |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Skin surface temperature Administration Topical Dermatology Dosage form Body Temperature Ointments Healthy volunteers Skin surface medicine Humans Prospective Studies skin and connective tissue diseases Patient compliance Analysis of Variance Topical drug Cross-Over Studies business.industry Abdominal skin Skin temperature Middle Aged Surgery Pharmaceutical Solutions Patient Compliance Female business Biomedical engineering |
| Zdroj: | The British journal of dermatology. 145(2) |
| ISSN: | 0007-0963 |
| Popis: | Background The efficacy of topical therapy depends on the patient spreading the topical drug in an even layer to give a standard dose. Ointments are believed to be more effective than creams and solutions. Objectives To compare the application and spreading of four different pharmaceutical vehicles. Methods Twenty-nine healthy volunteers applied a fixed amount (0·1 g) of solution (S), ointment (O), cream (C) and low-viscosity cream (LVC) to the abdominal skin. Area of spread, skin surface lipids (dependent on formulation) and changes in skin surface temperature (cooling due to evaporation of formulation water/alcohol) were measured. Results Area of spread: O = C = LVC = S. Skin surface lipids: O > C > LVC > S. Difference in skin surface lipids between centre and periphery: O |
| Databáze: | OpenAIRE |
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