Cerebrospinal fluid levels of markers of brain parenchymal damage in Vietnamese adults with severe malaria
| Autor: | Gareth D. H. Turner, Nguyen Hoan Phu, Tran Thi Hong Chau, Ly Van Chuong, Tran Tinh Hien, Jeremy Farrar, Ralf-Björn Lindert, Nguyen Thi Hoang Mai, Nicholas J. White, Isabelle M. Medana, Nicholas P. J. Day, Ulrich Wurster |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Enolase Central nervous system Tau protein Malaria Cerebral Enzyme-Linked Immunosorbent Assay tau Proteins S100 Calcium Binding Protein beta Subunit Cerebrospinal fluid medicine Humans Nerve Growth Factors Retrospective Studies Coma biology S100 Proteins Public Health Environmental and Occupational Health General Medicine Middle Aged Prognosis medicine.disease Infectious Diseases medicine.anatomical_structure nervous system Phosphopyruvate Hydratase biology.protein Female Parasitology Neuron medicine.symptom Biomarkers Malaria Astrocyte |
| Popis: | Summary A retrospective study of cerebrospinal fluid (CSF) markers of brain parenchymal damage was conducted in Vietnamese adults with severe malaria. Three markers were analysed by immunoassays: the microtubule-associated protein tau, for degenerated axons; neuron-specific enolase (NSE), for neurons; and S100B for astrocytes. The mean concentration of tau proteins in the CSF was significantly raised in patients with severe malaria compared with controls ( P = 0.0003) as reported for other central nervous system diseases. By contrast, the mean concentration of NSE and S100B remained within the normal range. Tau levels were associated with duration of coma ( P = 0.004) and S100B was associated with convulsions ( P = 0.006). Concentrations of axonal and astrocyte degeneration markers also were associated with vital organ dysfunction. No association was found between the level of markers of brain parenchymal damage on admission and a fatal outcome. On admission to hospital, patients with severe malaria had biochemical evidence of brain parenchymal damage predominantly affecting axons. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|