A case-case analysis of women with breast cancer: predictors of interval vs screen-detected cancer
| Autor: | Irene Acerbi, Laura J. van't Veer, Jeffrey A. Tice, Yiwey Shieh, Edward Hadeler, Fiona M McAuley, Michelle E. Melisko, Martin Eklund, Nickolas Dreher, Laura J. Esserman, Madeline B. Matthys |
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| Rok vydání: | 2022 |
| Předmět: |
Oncology
Adult Cancer Research medicine.medical_specialty Aging Clinical Sciences Oncology and Carcinogenesis Breast Cancer Surveillance Consortium Breast Neoplasms Logistic regression Article Interval cancer Breast cancer Clinical Research Internal medicine medicine Odds Ratio Humans Mass Screening 2.1 Biological and endogenous factors Oncology & Carcinogenesis Stage (cooking) Aetiology Early Detection of Cancer Aged Cancer screening and diagnosis Screen detected business.industry Prevention Odds ratio Middle Aged Supplemental screening medicine.disease Detection Breast density Screening Female 4.4 Population screening business Mammography 4.2 Evaluation of markers and technologies |
| Zdroj: | Breast cancer research and treatment, vol 191, iss 3 Breast Cancer Res Treat |
| Popis: | PurposeThe Breast Cancer Surveillance Consortium (BCSC) model is a widely used risk model that predicts 5- and 10-year risk of developing invasive breast cancer for healthy women aged 35-74years. Women with high BCSC risk may also be at elevated risk to develop interval cancers, which present symptomatically in the year following a normal screening mammogram. We examined the association between high BCSC risk (defined as the top 2.5% by age) and breast cancers presenting as interval cancers.MethodsWe conducted a case-case analysis among women with breast cancer in which we compared the mode of detection and tumor characteristics of patients in the top 2.5% BCSC risk by age with age-matched (1:2) patients in the lower 97.5% risk. We constructed logistic regression models to estimate the odds ratio (OR) of presenting with interval cancers, and poor prognosis tumor features, between women from the top 2.5% and bottom 97.5% of BCSC risk.ResultsOur analysis included 113 breast cancer patients in the top 2.5% of risk for their age and 226 breast cancer patients in the lower 97.5% of risk. High-risk patients were more likely to have presented with an interval cancer within one year of a normal screening, OR 6.62 (95% CI 3.28-13.4, p |
| Databáze: | OpenAIRE |
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