Effects of galvanic vestibular stimulation on resting state brain activity in patients with bilateral vestibulopathy

Autor: Martin Göttlich, Matthias Rother, Andreas Sprenger, Christoph Helmchen, Peer Spliethoff, Björn Machner
Rok vydání: 2020
Předmět:
Male
genetic structures
Brain activity and meditation
Bilateral Vestibulopathy
Audiology
0302 clinical medicine
Cerebellum
Research Articles
Cerebral Cortex
Vestibular system
Neuronal Plasticity
Radiological and Ultrasound Technology
05 social sciences
Amplitude of low frequency fluctuations
Middle Aged
Magnetic Resonance Imaging
rs‐fMRI
medicine.anatomical_structure
Neurology
Female
Anatomy
Research Article
medicine.medical_specialty
fALFF
degree centrality
Dizziness
050105 experimental psychology
03 medical and health sciences
Connectome
medicine
Humans
0501 psychology and cognitive sciences
Radiology
Nuclear Medicine and imaging
Kinesthesis
Galvanic vestibular stimulation
Aged
Resting state fMRI
business.industry
functional connectivity
Vestibular nerve
medicine.disease
Bilateral vestibulopathy
Electric Stimulation
Visual cortex
galvanic vestibular stimulation
visual–vestibular interaction
Neurology (clinical)
Nerve Net
business
030217 neurology & neurosurgery
Zdroj: Human Brain Mapping
ISSN: 1097-0193
1065-9471
DOI: 10.1002/hbm.24963
Popis: We examined the effect of galvanic vestibular stimulation (GVS) on resting state brain activity using fMRI (rs‐fMRI) in patients with bilateral vestibulopathy. Based on our previous findings, we hypothesized that GVS, which excites the vestibular nerve fibers, (a) increases functional connectivity in temporoparietal regions processing vestibular signals, and (b) alleviates abnormal visual–vestibular interaction. Rs‐fMRI of 26 patients and 26 age‐matched healthy control subjects was compared before and after GVS. The stimulation elicited a motion percept in all participants. Using different analyses (degree centrality, DC; fractional amplitude of low frequency fluctuations [fALFF] and seed‐based functional connectivity, FC), group comparisons revealed smaller rs‐fMRI in the right Rolandic operculum of patients. After GVS, rs‐fMRI increased in the right Rolandic operculum in both groups and in the patients' cerebellar Crus 1 which was related to vestibular hypofunction. GVS elicited a fALFF increase in the visual cortex of patients that was inversely correlated with the patients' rating of perceived dizziness. After GVS, FC between parietoinsular cortex and higher visual areas increased in healthy controls but not in patients. In conclusion, short‐term GVS is able to modulate rs‐fMRI in healthy controls and BV patients. GVS elicits an increase of the reduced rs‐fMRI in the patients' right Rolandic operculum, which may be an important contribution to restore the disturbed visual–vestibular interaction. The GVS‐induced changes in the cerebellum and the visual cortex were associated with lower dizziness‐related handicaps in patients, possibly reflecting beneficial neural plasticity that might subserve visual–vestibular compensation of deficient self‐motion perception.
Databáze: OpenAIRE
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