Age-Related Correlation Between Antioxidant Enzymes and DNA Damage With Smoking and Body Mass Index
| Autor: | Parvathi Kumara Reddy Thavanati, Jose Maria Cantu Garza, Aurora Escoto de Dios, Kodanda Reddy Kanala |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Aging medicine.medical_specialty Antioxidant DNA damage medicine.medical_treatment medicine.disease_cause Antioxidants Body Mass Index Superoxide dismutase chemistry.chemical_compound Internal medicine medicine Humans Lymphocytes Obesity Aged Glutathione Transferase Free-radical theory of aging Aged 80 and over biology Superoxide Dismutase Superoxide business.industry Smoking Glutathione Middle Aged Catalase Oxidative Stress Endocrinology Biochemistry chemistry biology.protein Geriatrics and Gerontology business Oxidative stress DNA Damage |
| Zdroj: | The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 63:360-364 |
| ISSN: | 1758-535X 1079-5006 |
| DOI: | 10.1093/gerona/63.4.360 |
| Popis: | To understand whether oxidants contribute to the initiation and/or promulgation toward aging, the present study has been undertaken on 220 healthy male volunteers aged 20-80 years selected from the defined electoral area (suburbs of Tirupati, Andhra Pradesh, India) to evaluate the concentrations of free radicals (superoxide anion, hydrogen peroxide), lymphocyte antioxidant enzymes (glutathione S-transferase, superoxide dismutase, catalase), and DNA damage in relation to obesity and smoking (lifestyles). A two fold increase of lymphocyte free radical generation (DNA damage) was observed in older age groups with a reduced antioxidant potential, forming a link between cigarette smoking and oxidative stress represented by an antioxidant imbalance. Body mass index had a positive relationship with oxidative stress, but antioxidant levels did not vary with body mass index. The findings conclude that free radical-mediated oxidative stress and DNA damage accelerate with lifestyle variations under reduced antioxidant potential. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|