A study of association between platelet volume indices and ST elevation myocardial infarction
| Autor: | Madduma Mudiyanselage Priyamali Thusharika Jayasekera, Rajapaksha Arachchige Namal Kumarasiri Wijesinghe, Mohammedu Aroos Fathima Azra, Bhawani Yasassri Alvitigala, Darshana Kottahachchi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system Mean platelet volume 030204 cardiovascular system & hematology Coronary artery disease 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Platelet 030212 general & internal medicine Myocardial infarction cardiovascular diseases Thrombus Platelet distribution width Original Paper Receiver operating characteristic business.industry Platelet Distribution Width Area under the curve medicine.disease lcsh:RC666-701 Cardiology Cardiology and Cardiovascular Medicine business |
| Zdroj: | International Journal of Cardiology: Heart & Vasculature, Vol 21, Iss, Pp 7-10 (2018) International Journal of Cardiology. Heart & Vasculature |
| ISSN: | 2352-9067 |
| Popis: | Introduction and objective: ST elevation myocardial infarction (STEMI) is caused by formation of a thrombus at a ruptured atheromatous plaque. Larger platelets are enzymatically and metabolically more active and play a crucial role in thrombus formation. Our objective was to study the association between platelet volume indices (mean platelet volume (MPV) and platelet distribution width (PDW)) and STEMI. Methods: A hospital-based case control study to compare the platelet indices of 52 STEMI patients before commencing antiplatelet therapy and age and gender matched 52 controls who had no history of ischemic heart disease or antiplatelet therapy. Blood samples were collected to EDTA bottles and analyzed using Mindray BC 6800 automated analyzer. Results: STEMI patients had significantly increased mean MPV and PDW compared to the control group ((8.22 ± 0.99 fL vs 7.74 ± 0.69 fL, p = 0.005) and (15.81 ± 0.41 fL vs 15.62 ± 0.33 fL, p = 0.007) respectively). Significant positive correlation existed between MPV and PDW (R = 0.556, p = 0.000) and weak negative correlation in platelet count with MPV (R = −0.323, p = 0.019) and PDW (R = −0.309, p = 0.026) of STEMI patients. Receiver Operating Characteristic (ROC) curves showed that MPV and PDW with cutoff values of 7.55 fL, 15.55 fL and with Area under the curve (AUC) of 0.640, 0.620 respectively. The sensitivities and specificities were found to be 73.1%, 69.2% and 61.5%, 55.8% for MPV and PDW respectively. Conclusion: Increased MPV and PDW were found to have a significant association with STEMI and this test has the potential to be used as a preliminary test to identify high-risk patient for myocardial infarction. Keywords: Coronary artery disease, Mean platelet volume, Platelet distribution width |
| Databáze: | OpenAIRE |
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