Functional linear modeling of activity data shows analgesic-mediated improved sleep in dogs with spontaneous osteoarthritis pain
Autor: | Margaret E. Gruen, B.D.X. Lascelles, David R. Samson |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Male
medicine.medical_specialty 040301 veterinary sciences Analgesic Pain lcsh:Medicine Osteoarthritis Meloxicam Placebo Article 0403 veterinary science 03 medical and health sciences Dogs 0302 clinical medicine Physical medicine and rehabilitation Quality of life Sleep Initiation and Maintenance Disorders medicine Insomnia Animals Humans Dog Diseases lcsh:Science Analgesics Musculoskeletal system Multidisciplinary business.industry lcsh:R Linear model 04 agricultural and veterinary sciences medicine.disease Sleep in non-human animals Female lcsh:Q medicine.symptom Sleep business 030217 neurology & neurosurgery medicine.drug |
Zdroj: | Scientific Reports, Vol 9, Iss 1, Pp 1-6 (2019) Scientific Reports |
ISSN: | 2045-2322 |
Popis: | In humans, pain due to osteoarthritis has been demonstrated to be associated with insomnia and sleep disturbances that affect perception of pain, productivity, and quality of life. Dogs, which develop spontaneous osteoarthritis and represent an increasingly used model for human osteoarthritis, would be expected to show similar sleep disturbances. Further, these sleep disturbances should be mitigated by analgesic therapy. Previous efforts to quantify sleep in osteoarthritic dogs using accelerometry have not demonstrated a beneficial effect of analgesic therapy; this is despite owner-reported improvements in dogs’ sleep quality. However, analytic techniques for time-series accelerometry data have advanced with the development of functional linear modeling. Our aim was to apply functional linear modeling to accelerometry data from osteoarthritic dogs participating in a cross-over non-steroidal anti-inflammatory (meloxicam) drug trial. Significant differences in activity patterns were seen dogs receiving drug (meloxicam) vs. placebo, suggestive of improved nighttime resting (sleep) and increased daytime activity. These results align with owner-reported outcome assessments of sleep quality and further support dogs as an important translational model with benefits for both veterinary and human health. |
Databáze: | OpenAIRE |
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