Essential role for collectrin in renal amino acid transport
| Autor: | Renu Sarao, Dustin Singer, Christine Remy, J. Andrew Pospisilik, François Verrey, Victoria Makrides, Simone M. R. Camargo, Gerti Stange, Ursula Danilczyk, Andreas Richter, Sudha Arya, Chahira Benabbas, Carsten A. Wagner, Tamara Ramadan, Josef M. Penninger |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Amino Acid Transport Systems Xenopus Down-Regulation Kidney Cell Line Mice Dogs Downregulation and upregulation Renin–angiotensin system medicine Animals Amino Acids chemistry.chemical_classification Membrane Glycoproteins Multidisciplinary Angiotensin II receptor type 1 biology Cell Polarity Kidney metabolism Biological Transport Transporter biology.organism_classification Amino acid Mice Inbred C57BL medicine.anatomical_structure Biochemistry chemistry Oocytes Tyrosine Female |
| Zdroj: | Nature. 444:1088-1091 |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/nature05475 |
| Popis: | Angiotensin -converting enzyme 2 (ACE2) is a regulator of the renin angiotensin system involved in acute lung failure, cardiovascular functions and severe acute respiratory syndrome (SARS) infections in mammals. A gene encoding a homologue to ACE2, termed collectrin (Tmem27), has been identified in immediate proximity to the ace2 locus. The in vivo function of collectrin was unclear. Here we report that targeted disruption of collectrin in mice results in a severe defect in renal amino acid uptake owing to downregulation of apical amino acid transporters in the kidney. Collectrin associates with multiple apical transporters and defines a novel group of renal amino acid transporters. Expression of collectrin in Xenopus oocytes and Madin-Darby canine kidney (MDCK) cells enhances amino acid transport by the transporter B(0)AT1. These data identify collectrin as a key regulator of renal amino acid uptake. |
| Databáze: | OpenAIRE |
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