Clinical Use of Platelet-Rich Plasma to Promote Tendon–Bone Healing and Graft Maturation in Anterior Cruciate Ligament Reconstruction—A Randomized Controlled Study

Autor: Heng, Gong, Bin, Huang, Zhuozhao, Zheng, Ligong, Fu, Lianxu, Chen
Rok vydání: 2022
Předmět:
Zdroj: Indian Journal of Orthopaedics
ISSN: 1998-3727
0019-5413
DOI: 10.1007/s43465-021-00533-z
Popis: Background We investigated the effect of platelet-rich plasma (PRP) on tendon–bone healing and intra-articular graft (IAG) maturation after anterior cruciate ligament (ACL) reconstruction. Methods In this prospective randomized controlled study, 60 patients with ruptured ACLs were divided one-to-one into two groups (study and control). Patients were treated using single-bundle autologous hamstring autografts. Only patients in the study group were administered PRP. Knee function (pre-operative and three-, six-, and 12-month post-operative Lysholm activity, Tegner and International Knee Documentation Committee scores, femoral tunnel (FT) and tibial tunnel (TT) diameters measured with computed tomography (post-operative follow-up at 4 days and at 12 months), and magnetic resonance imaging signal/noise quotients of the IAG and graft in the FT (at 12 months) were used to evaluate tendon–bone healing and graft maturation. Results Patients’ knee function scores improved after ACL reconstruction, but there were no significant differences between groups. At 12 months, FT (study, 8.88 ± 1.46 mm; control, 8.42 ± 2.75 mm) and TT (study, 9.50 ± 1.07 mm; control, 9.99 ± 1.91 mm) diameters were larger than FT (study, 6.91 ± 0.74 mm; control, 7.30 ± 1.17 mm) and TT (study, 9.31 ± 0.83 mm; control, 9.36 ± 0.88 mm) diameters at 4 days; however, differences between groups were not significant (FT, P = 0.67; TT, P = 0.52). There were no significant differences between groups for signal/noise quotients of the IAG (study, 1.38 ± 0.70; control, 2.01 ± 0.62; P = 0.06) and FT-portion of the graft (study, 2.39 ± 1.22; control, 2.46 ± 0.83; P = 0.89). Conclusion PRP had no significant effect on reducing bone tunnel widening, accelerating tendon–bone healing, or improving knee function; however, PRP may improve IAG maturation. Trial registration Our study was first registered at Clinicaltrials.gov with registration No. NCT04659447 on 12/09/2020.
Databáze: OpenAIRE
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